Suebsamran Phalakornm, Choenchoopon Hansa, Rojanasaksothorn Suvit, Loiha Suraporn, Chamnan Parinya
J Med Assoc Thai. 2016 Jan;99 Suppl 1:S35-42.
Alcohol consumption has been reported to be associated with the risk of diabetes. However, few studies have examined alcohol consumption as a risk factor for pre-diabetes in Asian populations.
This study is an analytical cross-sectional study aimed at determining the relationship between alcoholic consumption and pre-diabetes. This study used data on 383,442 men and women participating in the Health Checks Ubon Ratchathani (HCUR) project in 2007. Pre-diabetes was defined as a fasting blood glucose of > 100-125 mg%. Data on alcohol consumption was questioned and categorized into six groups: never, occasionally, 1-2 times/month, 1-2 times/week, 3-4 times/week and every day. Multivariable logistic regression was performed to estimate the association between self-reported alcohol consumption and pre-diabetes.
The prevalence of pre-diabetes was 10.5% (11.2% and 9.7% in men and women, respectively). After adjusting for other risk factors, alcohol consumption was independently associated with pre-diabetes, with dose response relationship (adjusted odds ratio (OR(adj) of 1.80, 95% CI 1.53-2.11, p < 0.001 and 1.47, 95% CI 1.28-1.68, p < 0.001) for those who drank every day and 3-4 times a week, as compared to no consumption), but who drank 1-2 times/month is decreased risk of prediabetes (OR(adj) = 0.89, 95% CI, 0.82-0.97, p = 0.006). Similar findings were observed for men. Women who drank occasionally had a significantly decreased risk of pre-diabetes, compared with non-drinker in women (OR(adj) 0.95, 95% CI 0.91-0.99, p = 0.039). There was no interaction between alcohol consumption with other potential covariates.
Alcohol consumption was independently associated with the risk of pre-diabetes in a possibly dose response fashion. Mild-moderate alcohol consumption appeared to be related with a decreased risk.
据报道，饮酒与糖尿病风险相关。然而，很少有研究将饮酒作为亚洲人群糖尿病前期的危险因素进行研究。
本研究为分析性横断面研究，旨在确定饮酒与糖尿病前期之间的关系。本研究使用了2007年参与乌汶叻差他尼健康检查（HCUR）项目的383442名男性和女性的数据。糖尿病前期定义为空腹血糖>100 - 125mg%。询问饮酒数据并分为六组：从不饮酒、偶尔饮酒、每月1 - 2次、每周1 - 2次、每周3 - 4次和每天饮酒。进行多变量逻辑回归以估计自我报告的饮酒与糖尿病前期之间的关联。
糖尿病前期的患病率为10.5%（男性和女性分别为11.2%和9.7%）。在调整其他危险因素后，饮酒与糖尿病前期独立相关，存在剂量反应关系（与不饮酒者相比，每天饮酒和每周饮酒3 - 4次者的调整优势比（OR(adj)）分别为1.80，95%可信区间1.53 - 2.11，p < 0.001和1.47，95%可信区间1.28 - 1.68，p < 0.001），但每月饮酒1 - 2次者糖尿病前期风险降低（OR(adj)=0.89，95%可信区间0.82 - 0.97，p = 0.006）。男性也观察到类似结果。与不饮酒的女性相比，偶尔饮酒的女性糖尿病前期风险显著降低（OR(adj) 0.95，95%可信区间0.91 - 0.99，p = 0.039）。饮酒与其他潜在协变量之间没有相互作用。
饮酒与糖尿病前期风险独立相关，可能呈剂量反应关系。轻度至中度饮酒似乎与风险降低有关。
