Krzanowski Marcin, Januszek Rafał, Krzanowska Katarzyna, Kuźniewski Marek, Kopeć Jerzy, Chowaniec Eve, Sułowicz Władysław
Przegl Lek. 2015;72(6):277-81.
The staging system of chronic kidney disease (CKD) classification plays an important role in patients stratification according to disease activity. The aim of the study was to evaluate the frequency of appearance of consecutive stages of chronic kidney disease based on simplified MDRD formula in patients with diagnosed CKD. Additionally, relationship between eGFR values and selected biochemical parameters and comorbidities were analyzed.
The study was performed retrospectively in the group of 1176 patients (636 males and 540 females) aged between 17-98 years (mean 64.7) with creatinine level > 120 μmol/l and/or creatinine clearance < 90 ml/min/1.73 m2.
The highest percentage of patients were designated to the 3rd CKD stage. There were positive correlations between eGFR and Hb, Ht, Fe, LDL-Ch, AspAT, HbA1c and negative correlations between eGFR and age, mean and systolic blood pressure, as well as with P, K, iPTH, and uric acid concentration. Patients with cardiovascular diseases had significaintly lower eGFR values as compare with patients without such complications, respectively: atrial fibrillation, arterial hypertension, chronic heart failure, ischaemic heart disease (p < 0.01), and myocardial infarction (p < 0.04).
The highest percentage of patients with diagnosed CKD belong to the 3rd stage of disease. Patients with cardiovascular complications have significantly lower eGFR as compared with those without such disturbances.
慢性肾脏病（CKD）分期系统在根据疾病活动度对患者进行分层方面起着重要作用。本研究旨在评估基于简化MDRD公式的慢性肾脏病连续分期在已确诊CKD患者中的出现频率。此外，还分析了估算肾小球滤过率（eGFR）值与选定生化参数及合并症之间的关系。
本研究对1176例患者（636例男性和540例女性）进行了回顾性研究，这些患者年龄在17 - 98岁之间（平均64.7岁），肌酐水平>120μmol/l和/或肌酐清除率<90ml/min/1.73m²。
最高比例的患者被归为CKD 3期。eGFR与血红蛋白（Hb）、血细胞比容（Ht）、铁、低密度脂蛋白胆固醇（LDL-Ch）、谷草转氨酶（AspAT）、糖化血红蛋白（HbA1c）呈正相关，与年龄、平均血压和收缩压以及血磷（P）、血钾（K）、全段甲状旁腺激素（iPTH）和尿酸浓度呈负相关。与无此类并发症的患者相比，患有心血管疾病的患者eGFR值显著更低，分别为：心房颤动、动脉高血压、慢性心力衰竭、缺血性心脏病（p<0.01）和心肌梗死（p<0.04）。
已确诊CKD的患者中最高比例属于疾病3期。与无此类疾病的患者相比，患有心血管并发症的患者eGFR显著更低。
