Proinflammatory cytokines in periodontal diseases and certain systemic disorders.

Recent decades have brought significant progress in understanding the role of cytokines in many aspects of the development of periodontal disease associated with systemic disorders and increased risk of oral cancer. A thorough search of articles was carried out on the databases PubMed on the association of periodontal disease and obstetric pathologies, systemic diseases and cancer. Refs cited are examples of support already common idea that periodontal disease may affect the initiation and/or development of serious pathological conditions. Drawn from the literature review findings confirm that chronic untreated periodontal inflammatory processes have their own important part in promoting systemic diseases and also are associated with an increased risk of developing cancer diseases.