慢性骨髓炎中头颈癌的关联：一项全国性回顾性队列研究。
Association of Head and Neck Cancers in Chronic Osteomyelitis: A National Retrospective Cohort Study.
作者信息
Tsai Chia-Ta, Ho Mao-Wang, Lin Dana, Chen Hsuan-Ju, Muo Chih-Hsin, Tseng Chun-Hung, Su Wen-Chi, Lin Ming-Chia, Kao Chia-Hung
机构信息
From the Division of Infectious Disease, Department of Internal Medicine, China Medical University Hospital (C-TT, M-WH); Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University (C-TT, W-CS, C-HK); Management Office for Health Data, China Medical University Hospital (DL, H-JC, C-HM); School of Medicine, China Medical University (H-JC, C-HM); Department of Neurology, China Medical University Hospital (C-HT); School of Medicine, China Medical University College of Medicine, Taichung (C-HT); Department of Nuclear Medicine, E-Da Hospital, I-Shou University, Kaohsiung (M-CL); and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (C-HK).
出版信息
Medicine (Baltimore). 2016 Jan;95(3):e2407. doi: 10.1097/MD.0000000000002407.
The aim of study is to determine whether chronic osteomyelitis (COM) is linked to an increased risk of head and neck cancer (HNC).We identify 17,033 patients with osteomyelitis and 68,125 subjects without osteomyelitis during 1996 to 2010 periods. Multivariable Cox proportional hazards regression analysis was used to measure the hazard ratio (HR) of head and neck cancer for the osteomyelitis cohort compared with the comparison cohort.A total of 99 patients in the COM and 228 patients in the comparison cohort developed HNC during an average 5.12 years of follow-up period. The incidence rate of HNC in the COM cohort was 1.51-fold (95% confidence interval [CI]: 1.17-1.95) higher than that in the comparison cohort after adjusting gender, age, urbanization level, monthly income, and comorbidities. In subgroup analysis, younger (less than 45 years-old) and patients without comorbidities have greater risks (adjusted HR: 2.29 [95% CI:1.43-3.66] and 1.74 [95% CI:1.28-2.38] respectively).This study results suggested the association between COM and HNC, particularly in younger population and patients without comorbidities.
本研究的目的是确定慢性骨髓炎（COM）是否与头颈癌（HNC）风险增加相关。我们确定了1996年至2010年期间17033例骨髓炎患者和68125例无骨髓炎的受试者。采用多变量Cox比例风险回归分析来衡量骨髓炎队列与对照队列相比发生头颈癌的风险比（HR）。在平均5.12年的随访期内，COM队列中有99例患者发生HNC，对照队列中有228例患者发生HNC。在调整性别、年龄、城市化水平、月收入和合并症后，COM队列中HNC的发病率比对照队列高1.51倍（95%置信区间[CI]：1.17 - 1.95）。在亚组分析中，年龄较小（小于45岁）且无合并症的患者风险更高（调整后HR分别为：2.29 [95% CI：1.43 - 3.66]和1.74 [95% CI：1.28 - 2.38]）。本研究结果提示COM与HNC之间存在关联，尤其是在年轻人群和无合并症的患者中。
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