口腔和口咽癌。

Oral and oropharyngeal cancer.

作者信息

Huber Michaell A, Tantiwongkosi Bundhit

机构信息

Department of Comprehensive Dentistry, University of Texas Health Science Center, School of Dentistry, 7703 Floyd Curl Drive, Mail Code 7919, San Antonio, TX 78229, USA.

Department of Radiology, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, Mail Code 7800, San Antonio, TX 78229, USA; Department of Otolaryngology, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, Mail Code 7800, San Antonio, TX 78229, USA.

出版信息

Med Clin North Am. 2014 Nov;98(6):1299-321. doi: 10.1016/j.mcna.2014.08.005. Epub 2014 Sep 20.

DOI:10.1016/j.mcna.2014.08.005

PMID:25443678

Abstract

Oral and oropharyngeal cancer (OPC) is a complex and often relentless malignancy prone to local invasion and dissemination. Despite advances in understanding of the disease and improved therapeutic interventions, it continues to be diagnosed at an advanced stage and the survival rate remains poor. The financial cost of treating OPC may be the highest of all cancers in the United States and survivors often experience major detriments to quality of life. Major risk factors for OPC are tobacco, alcohol, areca nut, and human papillomavirus infection. This article updates medical practitioners on the causes, presentation, diagnosis, and management of OPC.

摘要

口腔和口咽癌（OPC）是一种复杂且通常难以控制的恶性肿瘤，易于局部侵袭和扩散。尽管在对该疾病的认识和治疗干预方面取得了进展，但它仍常在晚期被诊断出来，生存率仍然很低。在美国，治疗OPC的经济成本可能是所有癌症中最高的，幸存者的生活质量往往受到重大损害。OPC的主要风险因素是烟草、酒精、槟榔和人乳头瘤病毒感染。本文向医学从业者介绍了OPC的病因、表现、诊断和管理的最新情况。