Nishimura R, Nagao K, Matsuda M, Baba K, Matsuoka Y, Ueno Y, Morinaga H, Nagase H, Miyayama O, Hamada T
Dept. of Surgery, Kumamoto Municipal Hospital.
Gan No Rinsho. 1989 Oct;35(12):1417-20.
DNA polymerase alpha activity is associated with cell proliferation, independently of the cell cycle phase, and a simple and reproducible method for the immunohistochemical demonstration of DNA polymerase alpha has been developed. In an analysis of a total of 76 human breast cancer tissues using this procedure, the clinico-pathological findings revealed that only the estrogen receptor (ER) significantly correlated with the DNA polymerase alpha activity. Therefore, this suggests that ER-negative tumors had a higher proliferative activity.
DNA聚合酶α活性与细胞增殖相关，与细胞周期阶段无关，并且已经开发出一种简单且可重复的免疫组织化学方法来显示DNA聚合酶α。使用该方法对总共76个人类乳腺癌组织进行分析，临床病理结果显示只有雌激素受体（ER）与DNA聚合酶α活性显著相关。因此，这表明ER阴性肿瘤具有更高的增殖活性。
