Misonou J, Iwabuchi K, Aizawa M, Murakami S
First Department of Pathology, Hokkaido University, School of Medicine, Sapporo, Japan.
Jpn J Surg. 1989 Jul;19(4):474-9. doi: 10.1007/BF02471631.
A 59-year-old Japanese man who had recently noticed a gradual enlargement in a nodule located in the left anterior part of his neck was admitted for surgical treatment. The histopathological features of the resected tumor were consistent with a typical lymphoepithelial cyst, however, the inner surface epithelium of the cyst showed histological transition to mucoepidermoid carcinoma, which was partially invading the cyst wall. Despite clinical efforts in a systemic search, no primary lesions which could have metastasized were found. The patient hasn't shown any evidence of recurrence since his tumor resection over 2 years ago. Besides this rare case report, a review of the English literature reveals 22 cases of possible branchiogenic carcinoma over the last 10 years, including 21 cases whose histological features were of squamous cell carcinoma and 1 whose histological features revealed mucoepidermoid carcinoma. The present case is thus only the second proven case of low-grade mucoepidermoid carcinoma arising within a branchiogenic cyst.
一名59岁的日本男性，近期发现位于其颈部左前部的一个结节逐渐增大，遂入院接受手术治疗。切除肿瘤的组织病理学特征符合典型的淋巴上皮囊肿，然而，囊肿的内表面上皮显示出向黏液表皮样癌的组织学转变，且部分侵犯囊肿壁。尽管进行了全面的临床检查，未发现可能发生转移的原发病变。自2年多前肿瘤切除以来，该患者未出现任何复发迹象。除了这份罕见病例报告外，对英文文献的回顾显示，在过去10年中有22例可能的鳃源性癌病例，其中21例组织学特征为鳞状细胞癌，1例组织学特征为黏液表皮样癌。因此，本病例是第二例经证实的起源于鳃源性囊肿的低级别黏液表皮样癌病例。
