Hussain Raza, Jamshed Arif, Iqbal Hassan, Usman Sadaf, Irfan Muhammad, Hafeez Bhatti Abu Bakar
Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
Department of Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
J Pak Med Assoc. 2016 Feb;66(2):187-93.
To determine the outcome in patients with early squamous cell carcinoma of oral tongue, and the impact of various prognostic factors on survival.
The retrospective study was conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised records of patients treated for squamous cell carcinoma of early stage tongue between March 2003 and October 2009. Various factors, including demographics, risk factors, stage, and grade of the tumour were determined. Kaplan Meier curves were plotted to determine the 5-year overall survival, relapse-free survival, local control, regional control, and loco-regional control.
A total of 137 patients with early oral tongue tumours were treated. With a median follow-up of 46 months, the overall survival of T1, T2 early tongue tumour was 73% and 64%. The incidence of occult metastasis was 30%. The overall survival for Stage I/II and III/IV was 78% and 50% (p=0.002). Patterns of failures included; local 19 (13%), regional 22 (16%), loco-regional 4 (3%) and distant 5 (4%) respectively. The 5-year local control, regional control, loco-regional control was 86%, 82% and 72%. The only significant predictor of overall survival was clinical and pathological N stage in T1 patients, and surgical procedure, grade, pathological N stage in T2 cases.
Treatment of early squamous cell carcinoma of oral tongue effectively achieved local control and disease-free survival. Nodal stage was the most important prognostic factor in terms of survival and recurrence.
确定早期舌鳞状细胞癌患者的预后情况，以及各种预后因素对生存的影响。
该回顾性研究在巴基斯坦拉合尔的绍卡特·汗姆纪念癌症医院及研究中心开展，纳入了2003年3月至2009年10月期间接受早期舌鳞状细胞癌治疗的患者记录。确定了包括人口统计学、危险因素、肿瘤分期和分级等各种因素。绘制Kaplan Meier曲线以确定5年总生存率、无复发生存率、局部控制率、区域控制率和局部区域控制率。
共治疗了137例早期舌部肿瘤患者。中位随访时间为46个月，T1、T2期早期舌肿瘤的总生存率分别为73%和64%。隐匿性转移发生率为30%。I/II期和III/IV期的总生存率分别为78%和50%（p = 0.002）。失败模式包括：局部19例（13%）、区域22例（16%）、局部区域4例（3%）和远处转移5例（4%）。5年局部控制率、区域控制率、局部区域控制率分别为86%、82%和72%。T1患者总生存的唯一显著预测因素是临床和病理N分期，T2患者则是手术方式、分级、病理N分期。
早期舌鳞状细胞癌的治疗有效地实现了局部控制和无病生存。就生存和复发而言，淋巴结分期是最重要的预后因素。
