Okorie Patricia N, de Souza Dziedzom K
Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria
Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Trans R Soc Trop Med Hyg. 2016 Feb;110(2):90-7. doi: 10.1093/trstmh/trv104.
Lymphatic filariasis (LF) is a debilitating disease caused by Wuchereria bancrofti, Brugia malayi and B. timori parasitic worms and transmitted by Culex, Anopheles, Aedes and Mansonia mosquitoes. Mass drug administration (MDA) to reduce the infection levels in the human population is the key component of LF elimination programs. However, the potential of the use of vector control is gaining recognition as a tool that can complement MDA. The method of monitoring the parasites in mosquito vectors is known as xenomonitoring. Monitoring of vectors for filarial larvae is an important assessment tool for LF elimination programs. Xenomonitoring has the advantage of giving a real-time estimate of disease, because the pre-patent period may take months after infection in humans. It is a non-invasive sensitive tool for assessing the presence of LF in endemic areas. The aim of this review is to discuss the prospects, challenges and needs of xenomonitoring as a public health tool, in the post-MDA evaluation activities of national LF elimination programs.
淋巴丝虫病（LF）是由班氏吴策线虫、马来布鲁线虫和帝汶布鲁线虫寄生蠕虫引起的一种使人衰弱的疾病，通过库蚊、按蚊、伊蚊和曼蚊传播。大规模药物给药（MDA）以降低人群中的感染水平是淋巴丝虫病消除计划的关键组成部分。然而，使用病媒控制作为一种可以补充MDA的工具的潜力正日益得到认可。监测蚊媒中寄生虫的方法称为异体监测。监测蚊媒中的丝虫幼虫是淋巴丝虫病消除计划的一项重要评估工具。异体监测具有实时估计疾病的优势，因为人体感染后的潜伏期可能长达数月。它是评估流行地区淋巴丝虫病存在情况的一种非侵入性敏感工具。本综述的目的是讨论在国家淋巴丝虫病消除计划的MDA后评估活动中，异体监测作为一种公共卫生工具的前景、挑战和需求。
