银介导的苯乙烯与α-羰基烷基溴化物和吲哚的分子间 1,2-烷基芳基化反应。
Silver-Mediated Intermolecular 1,2-Alkylarylation of Styrenes with α-Carbonyl Alkyl Bromides and Indoles.
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China.
出版信息
Angew Chem Int Ed Engl. 2016 Feb 24;55(9):3187-91. doi: 10.1002/anie.201511624. Epub 2016 Jan 28.
A new iron-facilitated silver-mediated radical 1,2-alkylarylation of styrenes with α-carbonyl alkyl bromides and indoles is described, and two new C-C bonds were generated in a single step through a sequence of intermolecular C(sp(3)-Br functionalization and C(sp(2))-H functionalization across the alkenes. This method provides an efficient access to alkylated indoles with broad substrate scope and excellent selectivity.
一种新的铁促进的银介导的自由基 1,2-烷芳基化反应，涉及α-羰基烷基溴化物和吲哚与苯乙烯的反应，通过一系列的分子间 C(sp(3)-Br 官能化和 C(sp(2))-H 官能化反应，在单个步骤中生成了两个新的 C-C 键。该方法提供了一种高效的方法，可用于广泛的底物范围和优异的选择性的烷基化吲哚。
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