Bruneau N, Barthélémy C, Roux S, Jouve J, Lelord G
INSERM U316, CHU Bretonneau, Tours, France.
Neuropsychobiology. 1989;21(1):48-52. doi: 10.1159/000118551.
Evoked potentials to auditory stimulations varying in intensity were studied in 13 children with autistic behavior treated with fenfluramine. Modifications of both amplitude and single-trial potential variability were considered according to the clinical and biochemical responsiveness to this drug. Six children (responders) were clinically improved by the treatment. Electrophysiological data were affected according to the clinical and biochemical responsiveness to fenfluramine: the auditory evoked potential amplitude increased, and the single-trial potential variability decreased at each intensity level only in responders whose dopaminergic metabolism was significantly modified by fenfluramine treatment. No modification was found in nonresponders. Both biochemical and electrophysiological results argued for an amphetamine-like action of fenfluramine in those autistic children whose attention deficits are associated with motor disturbances including hyperactivity.
对13名接受芬氟拉明治疗的自闭症行为儿童进行了不同强度听觉刺激诱发电位的研究。根据对该药物的临床和生化反应性，考虑了振幅和单次试验电位变异性的变化。6名儿童（反应者）经治疗后临床症状改善。电生理数据受对芬氟拉明的临床和生化反应性影响：仅在多巴胺能代谢因芬氟拉明治疗而显著改变的反应者中，每个强度水平的听觉诱发电位振幅增加，单次试验电位变异性降低。在无反应者中未发现变化。生化和电生理结果均表明，在那些注意力缺陷与包括多动在内的运动障碍相关的自闭症儿童中，芬氟拉明具有类似苯丙胺的作用。
