原发性骨自然杀伤/T细胞淋巴瘤，鼻型，无EB病毒感染：一例报告
Primary bone natural killer/T cell lymphoma, nasal type without EBV infection: a case report.
作者信息
Tian Chen, Wang Yafei, Zhu Lei, Yu Yong, Zhang Yizhuo
机构信息
Cancer Institute and Hospital of Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin 300060, China.
出版信息
Int J Clin Exp Pathol. 2015 Nov 1;8(11):14836-9. eCollection 2015.
Abstract
Primary bone NK/T cell lymphoma is very rare. We report a case of 52-year-old man of primary bone NK/T cell lymphoma and then progressed to NK leukemia. The patient had low-grade fever for 4-month, and Ultrasonic B revealed a diffuse hepatosplenomegaly without lymphadenopathy. PET scanning showed increased FDG uptake in many bones of the whole body. The diagnosis was established by bone specimen. These neoplastic cells demonstrated a typical immunophenotype of CD56, CD3, CD2 and MPO positive, and CD5, CD20, CD30, PAX-5, CD4 and CD8 negative. Primary bone ENKTL is very rare; it should be made with the combination of clinical feature, PET-CT image, and pathological characteristics, and should be distinguished from other lymphomas or leukemia involved in bone.
摘要
原发性骨NK/T细胞淋巴瘤非常罕见。我们报告一例52岁男性原发性骨NK/T细胞淋巴瘤，随后进展为NK白血病。患者低热4个月，超声B显示弥漫性肝脾肿大，无淋巴结肿大。PET扫描显示全身多处骨骼FDG摄取增加。通过骨标本确诊。这些肿瘤细胞表现出典型的免疫表型，CD56、CD3、CD2和MPO阳性，CD5、CD20、CD30、PAX-5、CD4和CD8阴性。原发性骨ENKTL非常罕见；应结合临床特征、PET-CT图像和病理特征进行诊断，并应与累及骨骼的其他淋巴瘤或白血病相鉴别。
相似文献
1
Primary bone natural killer/T cell lymphoma, nasal type without EBV infection: a case report.
Int J Clin Exp Pathol. 2015 Nov 1;8(11):14836-9. eCollection 2015.
2
Primary spleen extranodal NK/T cell lymphoma, nasal type, with bone marrow involvement and CD30 positive expression: a case report and literature review.
Diagn Pathol. 2014 Sep 3;9:169. doi: 10.1186/s13000-014-0169-9.
3
Clinicopathological study of pulmonary extranodal nature killer/T-cell lymphoma, nasal type and literature review.
Pathol Res Pract. 2015 Jul;211(7):544-9. doi: 10.1016/j.prp.2015.04.002. Epub 2015 Apr 17.
4
Cutaneous peripheral T-cell lymphoma of cytotoxic phenotype mimicking extranodal NK/T-cell lymphoma.
Am J Dermatopathol. 2011 Apr;33(2):e17-20. doi: 10.1097/DAD.0b013e3181ea6571.
5
Extranodal NK/T-cell lymphoma in Tunisia: clinicopathological features, immunophenotype and EBV infection.
J Egypt Natl Canc Inst. 2019 Oct 22;31(1):1. doi: 10.1186/s43046-019-0002-3.
6
Clinicopathological analysis of the age-related differences in patients with Epstein-Barr virus (EBV)-associated extranasal natural killer (NK)/T-cell lymphoma with reference to the relationship with aggressive NK cell leukaemia and chronic active EBV infection-associated lymphoproliferative disorders.
Histopathology. 2011 Oct;59(4):660-71. doi: 10.1111/j.1365-2559.2011.03976.x.
7
A case of CD30+ nasal natural killer/T-cell lymphoma.
Am J Dermatopathol. 2008 Dec;30(6):567-71. doi: 10.1097/DAD.0b013e318184bc3f.
8
Nodal cytotoxic molecule (CM)-positive Epstein-Barr virus (EBV)-associated peripheral T cell lymphoma (PTCL): a clinicopathological study of 26 cases.
Histopathology. 2012 Aug;61(2):186-99. doi: 10.1111/j.1365-2559.2012.04199.x. Epub 2012 Jun 13.
9
Extranodal nasal-type natural killer/T-cell lymphoma with penile involvement: a case report and review of the literature.
BMC Urol. 2017 Sep 6;17(1):77. doi: 10.1186/s12894-017-0273-8.
10
Acute Epstein-Barr virus-positive cytotoxic T cell lymphoid hyperplasia in the upper aerodigestive tract, mimicking extranodal natural killer/T cell lymphoma, nasal type.
Virchows Arch. 2019 Feb;474(2):219-226. doi: 10.1007/s00428-018-2498-7. Epub 2018 Nov 28.
引用本文的文献
1
Nasal-type extranodal natural killer/T-cell lymphoma with oral ulcer as the earliest clinical manifestation.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2022 May 25;40(3):355-359. doi: 10.7518/hxkq.2022.03.017.
2
Primary Natural Killer/T-Cell Lymphoma of the Ribs.
Turk J Haematol. 2023 Feb 28;40(1):70-72. doi: 10.4274/tjh.galenos.2022.2022.0322. Epub 2022 Dec 2.
3
Rhino-Orbital-Cerebral Mycosis and Extranodal Natural Killer or/and T-Cell Lymphoma, Nasal Type.
Front Med (Lausanne). 2022 Jun 17;9:851208. doi: 10.3389/fmed.2022.851208. eCollection 2022.
4
What Effect Does Epstein-Barr Virus Have on Extranodal Natural Killer/T-Cell Lymphoma Prognosis? A Review of 153 Reported Cases.
Cureus. 2021 Sep 15;13(9):e17987. doi: 10.7759/cureus.17987. eCollection 2021 Sep.
5
Extranodal NK/T-cell lymphoma, nasal type without evidence of EBV infection.
Oncol Lett. 2020 Sep;20(3):2665-2676. doi: 10.3892/ol.2020.11842. Epub 2020 Jul 9.
本文引用的文献
1
Effectiveness of gemcitabine, pegaspargase, cisplatin, and dexamethasone (DDGP) combination chemotherapy in the treatment of relapsed/refractory extranodal NK/T cell lymphoma: a retrospective study of 17 patients.
Ann Hematol. 2014 Nov;93(11):1889-94. doi: 10.1007/s00277-014-2136-7. Epub 2014 Jun 13.
2
Extranodal natural killer/T-cell lymphoma involving the gastrointestinal tract: analysis of clinical features and outcomes from the Asia Lymphoma Study Group.
J Hematol Oncol. 2013 Nov 16;6:86. doi: 10.1186/1756-8722-6-86.
3
Retrospective study of modified SMILE chemotherapy for advanced-stage, relapsed, or refractory extranodal natural killer (NK)/T cell lymphoma, nasal type.
Med Oncol. 2013 Dec;30(4):720. doi: 10.1007/s12032-013-0720-7. Epub 2013 Sep 24.
4
An extraordinary T/NK lymphoma, nasal type, occurring primarily in the prostate gland with unusual CD30 positivity: case report and review of the literature.
Diagn Pathol. 2013 Jun 17;8:94. doi: 10.1186/1746-1596-8-94.
5
First report of primary pancreatic natural killer/T-cell nasal type lymphoma.
Eur Rev Med Pharmacol Sci. 2013 Feb;17(3):318-22.
6
Flow cytometric immunophenotyping is of great value to diagnosis of natural killer cell neoplasms involving bone marrow and peripheral blood.
Ann Hematol. 2013 Jan;92(1):89-96. doi: 10.1007/s00277-012-1574-3. Epub 2012 Sep 20.
7
NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax.
Diagn Pathol. 2012 Aug 29;7:114. doi: 10.1186/1746-1596-7-114.
8
Pretreatment EBV-DNA copy number is predictive of response and toxicities to SMILE chemotherapy for extranodal NK/T-cell lymphoma, nasal type.
Clin Cancer Res. 2012 Aug 1;18(15):4183-90. doi: 10.1158/1078-0432.CCR-12-1064. Epub 2012 Jun 6.
9
Aggressive natural killer cell leukemia: therapeutic potential of L-asparaginase and allogeneic hematopoietic stem cell transplantation.
Cancer Sci. 2012 Jun;103(6):1079-83. doi: 10.1111/j.1349-7006.2012.02251.x. Epub 2012 Mar 23.
10
Long-term outcomes of patients with newly diagnosed extranodal natural killer/T-cell lymphoma treated by etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin regimen: a single-institution experience.
Leuk Lymphoma. 2011 Jun;52(6):1041-8. doi: 10.3109/10428194.2011.561388.
Zotero 插件