二氧化硅暴露受试者的骨密度和25-羟基维生素D水平评估。
Evaluation of bone mineral density and 25-hydroxyvitamin D levels in subjects with silica exposure.
作者信息
Yıldızgören Mustafa Turgut, Öziş Türkan Nadir, Baki Ali Erdem, Tutkun Engin, Yılmaz Hınç, Tiftik Tülay, Ekiz Timur, Özgirgin Neşe
机构信息
Department of Physical Medicine and Rehabilitation, Ankara Occupational Diseases Hospital, Ankara, Turkey.
Department of Chest Diseases, Ankara Occupational Diseases Hospital, Ankara, Turkey.
出版信息
Environ Health Prev Med. 2016 May;21(3):149-53. doi: 10.1007/s12199-016-0509-3. Epub 2016 Jan 29.
OBJECTIVE
The purpose of the study was to evaluate the bone mineral density (BMD) and 25-hydroxyvitamin D (25(OH)D) levels in patients with silica exposure.
MATERIALS AND METHODS
The study included 104 male subjects with silica exposure and 36 healthy subjects. Posterior-anterior radiographs were classified according to the International Labour Office (ILO) Classification. Category 0 patients were classified as Group I (n = 54), category I patients were classified as Group II (n = 25), Category II and III patients were classified as Group III (n = 25).
RESULTS
Femoral neck BMD values were significantly lower in Group III (p = 0.007). Lumbar vertebrae BMD values were significantly lower in all groups with silica exposure than in the control group (p = 0.000). The osteoporosis rate was significantly higher in Group III (p = 0.000). Subjects with silica exposure were determined to have diminished 25(OH)D levels (p = 0.012).
CONCLUSION
The results of this study demonstrated that subjects with silica exposure have diminished BMD and 25(OH)D levels.
目的
本研究旨在评估接触二氧化硅患者的骨矿物质密度（BMD）和25-羟基维生素D（25(OH)D）水平。
材料与方法
本研究纳入104名接触二氧化硅的男性受试者和36名健康受试者。后前位X线片根据国际劳工组织（ILO）分类法进行分类。0类患者分为I组（n = 54），I类患者分为II组（n = 25），II类和III类患者分为III组（n = 25）。
结果
III组的股骨颈骨密度值显著更低（p = 0.007）。所有接触二氧化硅的组的腰椎骨密度值均显著低于对照组（p = 0.000）。III组的骨质疏松率显著更高（p = 0.000）。接触二氧化硅的受试者被确定25(OH)D水平降低（p = 0.012）。
结论
本研究结果表明，接触二氧化硅的受试者骨密度和25(OH)D水平降低。
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