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Osteoporosis: can it be related to silicosis?
Tuberk Toraks. 2014;62(1):98-9. doi: 10.5578/tt.5721.
2
The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis.炎性细胞因子、RANKL/OPG轴及免疫骨骼界面在生理性骨转换和骨质疏松症中的作用
Scientifica (Cairo). 2013;2013:125705. doi: 10.1155/2013/125705. Epub 2013 Feb 3.
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Male osteoporosis: A review.男性骨质疏松症：综述
World J Orthop. 2012 Dec 18;3(12):223-34. doi: 10.5312/wjo.v3.i12.223.
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Co-morbidities among silicotics at Shakarpur: A follow up study.沙卡尔布尔矽肺患者的合并症：一项随访研究。
Lung India. 2012 Jan;29(1):6-10. doi: 10.4103/0970-2113.92348.
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Determination of ameliorable health impairment influencing health-related quality of life among patients with silicosis in China: a cross-sectional study.
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6
Osteoporosis associated with pulmonary silicosis in an equine bone fragility syndrome.与马骨脆弱综合征相关的伴有肺硅沉着病的骨质疏松症。
Vet Pathol. 2011 May;48(3):593-615. doi: 10.1177/0300985810385151. Epub 2010 Nov 19.
7
A brief review of silicosis in the United States.美国矽肺病简述。
Environ Health Insights. 2010 May 18;4:21-6. doi: 10.4137/ehi.s4628.
8
Silica and the immune system.二氧化硅与免疫系统。
Acta Biomed. 2005;76 Suppl 2:38-44.
9
Basic pathogenetic mechanisms in silicosis: current understanding.矽肺的基本发病机制：当前的认识
Curr Opin Pulm Med. 2005 Mar;11(2):169-73. doi: 10.1097/01.mcp.0000152998.11335.24.
10
RANKL regulates Fas expression and Fas-mediated apoptosis in osteoclasts.核因子κB受体活化因子配体（RANKL）调节破骨细胞中Fas的表达和Fas介导的细胞凋亡。
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二氧化硅暴露受试者的骨密度和25-羟基维生素D水平评估。

Evaluation of bone mineral density and 25-hydroxyvitamin D levels in subjects with silica exposure.

作者信息

Yıldızgören Mustafa Turgut, Öziş Türkan Nadir, Baki Ali Erdem, Tutkun Engin, Yılmaz Hınç, Tiftik Tülay, Ekiz Timur, Özgirgin Neşe

机构信息

Department of Physical Medicine and Rehabilitation, Ankara Occupational Diseases Hospital, Ankara, Turkey.

Department of Chest Diseases, Ankara Occupational Diseases Hospital, Ankara, Turkey.

出版信息

Environ Health Prev Med. 2016 May;21(3):149-53. doi: 10.1007/s12199-016-0509-3. Epub 2016 Jan 29.

DOI:10.1007/s12199-016-0509-3
PMID:26825971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4823218/
Abstract

OBJECTIVE

The purpose of the study was to evaluate the bone mineral density (BMD) and 25-hydroxyvitamin D (25(OH)D) levels in patients with silica exposure.

MATERIALS AND METHODS

The study included 104 male subjects with silica exposure and 36 healthy subjects. Posterior-anterior radiographs were classified according to the International Labour Office (ILO) Classification. Category 0 patients were classified as Group I (n = 54), category I patients were classified as Group II (n = 25), Category II and III patients were classified as Group III (n = 25).

RESULTS

Femoral neck BMD values were significantly lower in Group III (p = 0.007). Lumbar vertebrae BMD values were significantly lower in all groups with silica exposure than in the control group (p = 0.000). The osteoporosis rate was significantly higher in Group III (p = 0.000). Subjects with silica exposure were determined to have diminished 25(OH)D levels (p = 0.012).

CONCLUSION

The results of this study demonstrated that subjects with silica exposure have diminished BMD and 25(OH)D levels.

摘要

目的

本研究旨在评估接触二氧化硅患者的骨矿物质密度（BMD）和25-羟基维生素D（25(OH)D）水平。

材料与方法

本研究纳入104名接触二氧化硅的男性受试者和36名健康受试者。后前位X线片根据国际劳工组织（ILO）分类法进行分类。0类患者分为I组（n = 54），I类患者分为II组（n = 25），II类和III类患者分为III组（n = 25）。

结果

III组的股骨颈骨密度值显著更低（p = 0.007）。所有接触二氧化硅的组的腰椎骨密度值均显著低于对照组（p = 0.000）。III组的骨质疏松率显著更高（p = 0.000）。接触二氧化硅的受试者被确定25(OH)D水平降低（p = 0.012）。

结论

本研究结果表明，接触二氧化硅的受试者骨密度和25(OH)D水平降低。