使用负荷剂量维生素D治疗肠衰竭患者的维生素D缺乏症。
Use of a Loading Dose of Vitamin D for Treatment of Vitamin D Deficiency in Patients With Intestinal Failure.
作者信息
Grenade Neil, Kosar Christina, Steinberg Karen, Avitzur Yaron, Wales Paul W, Courtney-Martin Glenda
机构信息
1 Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
2 Group for Improvement of Intestinal Function and Treatment, The Hospital for Sick Children, Toronto, Ontario, Canada.
出版信息
JPEN J Parenter Enteral Nutr. 2017 Mar;41(3):512-516. doi: 10.1177/0148607115625220. Epub 2016 Jul 11.
Vitamin D deficiency is common in patients with intestinal failure and short bowel syndrome who have been weaned of parenteral nutrition. Dietary supplementation with vitamin D is necessary to correct this deficiency. In certain cases, routine supplementation strategy may be ineffective. We report 3 cases of vitamin D deficiency in patients with intestinal failure who showed improvement in serum 25-hydroxyvitamin D levels after supplementation with a loading dose of 20,000-40,000 IU vitamin D provided weekly.
维生素D缺乏在已停用肠外营养的肠衰竭和短肠综合征患者中很常见。通过饮食补充维生素D对于纠正这种缺乏是必要的。在某些情况下，常规的补充策略可能无效。我们报告了3例肠衰竭患者维生素D缺乏的病例，这些患者在每周补充20,000 - 40,000 IU维生素D的负荷剂量后，血清25 - 羟基维生素D水平有所改善。
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