Margulies Samantha L, Kurian Divya, Elliott Mark S, Han Zhiyong
George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
J Dig Dis. 2015 Nov;16(11):617-33. doi: 10.1111/1751-2980.12283.
There is a very high prevalence of vitamin D deficiency, which is defined by a serum level of 25-hydroxyvitamin D [25(OH)D] of lower than 20 ng/mL, in all populations of the world. Unfortunately, the prevalence of vitamin D deficiency in patients with intestinal malabsorption syndromes, including cystic fibrosis (CF), celiac disease (CD), short bowel syndrome and inflammatory bowel disease (IBD), is higher than that in the general population, indicating the presence of disease-specific causative factors. In this review, we aimed to present clinical findings to highlight the roles of insufficient exposure to sunlight and inflammation in the development of vitamin D deficiency in patients with intestinal malabsorption syndromes. Furthermore, we aimed to present experimental evidence that supported a role of vitamin D deficiency in the pathogenesis of IBD. Finally, we reviewed clinical intervention strategies aiming to normalize vitamin D status in and even to improve the conditions of patients and to discuss certain issues that needed to be addressed in future research.
全球所有人群中维生素D缺乏症的患病率都非常高，维生素D缺乏症的定义是血清25-羟基维生素D [25(OH)D]水平低于20 ng/mL。不幸的是，包括囊性纤维化（CF）、乳糜泻（CD）、短肠综合征和炎症性肠病（IBD）在内的肠道吸收不良综合征患者中维生素D缺乏症的患病率高于普通人群，这表明存在疾病特异性致病因素。在本综述中，我们旨在展示临床研究结果，以突出阳光照射不足和炎症在肠道吸收不良综合征患者维生素D缺乏症发生过程中的作用。此外，我们旨在展示实验证据，支持维生素D缺乏症在IBD发病机制中的作用。最后，我们回顾了旨在使患者维生素D状态正常化甚至改善患者病情的临床干预策略，并探讨了未来研究中需要解决的一些问题。
