Cheng Qun, Tang Wenjing, Sheu Tzong-Jen, Du Yanping, Gan Jiemin, Li Huilin, Hong Wei, Zhu Xiaoying, Xue Sihong, Zhang Xuemei
Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, China; Research Center on Aging and Medicine, Fudan University, China.
Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, China; Research Center on Aging and Medicine, Fudan University, China.
Clin Chim Acta. 2016 Apr 1;455:87-92. doi: 10.1016/j.cca.2016.01.025. Epub 2016 Jan 28.
TGF-β1 regulates bone metabolism and mediates bone turnover during postmenopause. Sclerostin negatively regulates Wnt signaling pathway and also has an important role in postmenopausal bone loss. Little is known about the relationship between serum TGF-β1 and sclerostin during menopause.
We compared serum levels of TGF-β1 and sclerostin in pre- and postmenopausal women and assessed the potential correlations of these levels with each other and with serum levels of bone turnover markers and bone mineral density.
A total of 176 women (58 premenopausal, 62 early postmenopausal, and 56 late postmenopausal) were included in this study. Serum TGF-β1 level was significantly higher in early postmenopausal women compared with premenopausal (32.0±7.19 vs. 26.55±6.67 ng/ml, p=0.01) and late postmenopausal (32.0±7.19 vs. 28.65±7.70 pg/ml, p=0.031) women, and no significant differences in serum sclerostin levels were observed among the 3 groups. There was a significant negative correlation between TGF-β1 and sclerostin in early postmenopausal women, but not in other groups of women. Based on multiple regression analysis, only TGF-β1 (β=-0.362; p=0.007) was an independent predictor of sclerostin during early postmenopause.
Our findings suggest that serum TGF-β1 level increases during postmenopause and declines in old age. Sclerostin production is inhibited by TGF-β1 during early postmenopause.
转化生长因子-β1（TGF-β1）调节骨代谢并在绝经后介导骨转换。硬化素对Wnt信号通路起负调节作用，在绝经后骨质流失中也起重要作用。关于绝经期间血清TGF-β1与硬化素之间的关系知之甚少。
我们比较了绝经前和绝经后女性血清中TGF-β1和硬化素水平，并评估了这些水平之间以及与骨转换标志物血清水平和骨密度的潜在相关性。
本研究共纳入176名女性（58名绝经前女性、62名绝经早期女性和56名绝经晚期女性）。绝经早期女性血清TGF-β1水平显著高于绝经前女性（32.0±7.19对26.55±6.67 ng/ml，p = 0.01）和绝经晚期女性（32.0±7.19对28.65±7.70 pg/ml，p = 0.031），三组间血清硬化素水平未观察到显著差异。绝经早期女性中TGF-β1与硬化素之间存在显著负相关，而其他组女性中未观察到。基于多元回归分析，在绝经早期，只有TGF-β1（β = -0.362；p = 0.007）是硬化素的独立预测因子。
我们的研究结果表明，血清TGF-β1水平在绝经后升高，在老年时下降。在绝经早期，TGF-β1抑制硬化素的产生。
