大唾液腺嗜酸细胞癌：一项基于人群的278例病例研究。
Oncocytic carcinoma of the major salivary glands: A population-based study of 278 cases.
作者信息
Zhan Kevin Y, Lentsch Eric J
机构信息
Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
出版信息
Head Neck. 2016 Apr;38 Suppl 1:E1981-6. doi: 10.1002/hed.24363. Epub 2016 Feb 1.
BACKGROUND
Oncocytic carcinomas of the major salivary glands are extremely rare, with <100 cases reported.
METHODS
A retrospective review of the National Cancer Database was performed from 1998 to 2012.
RESULTS
We found 278 cases of major salivary oncocytic carcinoma. Most patients were men (61.9%), white (84.8%), with parotid disease (88.5%). Median age was 67 years (range, 16-90 years). Regional and distant metastases were found in 36.4% and 4.7% of cases. Overall survival at 5 and 10-years was 64% and 39%, respectively. Distant metastasis (hazard ratio [HR] = 13.87; 95% confidence interval [CI] = 2.98-64.52; p = .0010) and regional metastasis (HR = 3.01; 95% CI = 1.20-7.55; p = .019) are significant negative predictors, whereas positive margins approached significance (HR = 3.01; 95% CI = 1.20-7.55; p = .074).
CONCLUSION
Oncocytic carcinoma has a poor long-term prognosis and lymph node metastases are common. Distant and regional metastases are significant predictors of decreased survival. © 2016 Wiley Periodicals, Inc. Head Neck 38: E1981-E1986, 2016.
背景
大唾液腺嗜酸细胞癌极为罕见，报告病例不足100例。
方法
对1998年至2012年国家癌症数据库进行回顾性分析。
结果
我们发现了278例大唾液腺嗜酸细胞癌病例。大多数患者为男性（61.9%），白人（84.8%），患有腮腺疾病（88.5%）。中位年龄为67岁（范围16 - 90岁）。36.4%的病例出现区域转移，4.7%的病例出现远处转移。5年和10年总生存率分别为64%和39%。远处转移（风险比[HR]=13.87；95%置信区间[CI]=2.98 - 64.52；p = 0.0010）和区域转移（HR = 3.01；95% CI = 1.20 - 7.55；p = 0.019）是显著的负性预测因素，而切缘阳性接近显著水平（HR = 3.01；95% CI = 1.20 - 7.55；p = 0.074）。
结论
嗜酸细胞癌长期预后较差，淋巴结转移常见。远处和区域转移是生存率降低的显著预测因素。© 2016威利期刊公司。头颈外科38: E1981 - E1986, 2016。
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