DeLisi L E, Crow T J
Dept. of Psychiatry, SUNY, Stony Brook 11974.
Schizophr Bull. 1989;15(3):431-40. doi: 10.1093/schbul/15.3.431.
The sex chromosomes are strong candidates for a genetic locus for schizophrenia and the affective psychoses. Gender differences in the clinical expression of illness and familial risks, concordance for gender and illness in relatives, and an association of X chromosome anomalies with psychosis suggest an X chromosome locus. The presence of male-to-male transmission in some families, in the face of a lack of strong evidence for heterogeneity, specifically focuses the search within the pseudoautosomal region of the X and Y chromosomes where sequence homology and recombination takes place.
性染色体是精神分裂症和情感性精神病基因位点的有力候选者。疾病临床表型和家族风险中的性别差异、亲属中性别与疾病的一致性，以及X染色体异常与精神病的关联提示存在一个X染色体位点。在缺乏明显异质性证据的情况下，一些家族中存在男性与男性之间的传递，这使得搜索特别聚焦于X和Y染色体的拟常染色体区域，该区域存在序列同源性和重组。
