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Human chromosome 12 is required for elevated HIV-1 expression in human-hamster hybrid cells.

作者信息

Hart C E, Ou C Y, Galphin J C, Moore J, Bacheler L T, Wasmuth J J, Petteway S R, Schochetman G

机构信息

Centers for Disease Control, Atlanta, GA 30333.

出版信息

Science. 1989 Oct 27;246(4929):488-91. doi: 10.1126/science.2683071.

DOI:10.1126/science.2683071
PMID:2683071
Abstract

Host cell factors act together with regulatory genes of the human immunodeficiency virus (HIV) to control virus production. Human-Chinese hamster ovary hybrid cell clones were used to probe for human chromosomes involved in regulating HIV gene expression. DNA transfection experiments showed that 4 of 18 clones had high levels of HIV gene expression measured by both extracellular virus production and transactivation of the HIV long terminal repeat in the presence of the trans-activator (tat) gene. Karyotype analyses revealed a 94% concordance (17/18) between human chromosome 12 and HIV gene expression. Other chromosomes had an 11 to 72% concordance with virus production.

摘要

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