McBride Andrew, Khan Hussain Ijaz, Aitken Dawn, Chou Louisa, Ding Changhai, Blizzard Leigh, Pelletier Jean-Pierre, Martel-Pelletier Johanne, Cicuttini Flavia, Jones Graeme
Menzies Institute for Medical Research, University of Tasmania, Medical Science 1 Building, Private Bag 23 17-Liverpool Street, Hobart, 7000, Australia.
Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada.
BMC Musculoskelet Disord. 2016 Feb 2;17:54. doi: 10.1186/s12891-016-0900-7.
The aim of this study was to examine whether cartilage volume as measured by MRI and radiographic osteoarthritis (OA) at baseline predict cartilage volume loss over ten years independent of each other and other structural co-pathologies.
219 participants [mean-age 45(26-61); 57 % female] were studied at baseline and ten years. Approximately half were the adult offspring of subjects who underwent knee replacement for OA and the remainder were randomly selected controls. Joint space narrowing (JSN) and osteophytes were assessed on radiographs and cartilage volume (tibiofemoral), cartilage defects, bone marrow lesions and meniscal tears/extrusion were assessed on MRI.
Mean absolute and percentage per annum cartilage volume loss was 1284 mm(3) and 1.91 % respectively in the medial compartment and 1007 mm(3) and 1.38 % respectively in the lateral compartment. Higher baseline tibiofemoral cartilage volume was independently associated with greater absolute cartilage volume loss in both medial (β(95 % CI) = -300 (-399,-200)) and lateral (β = -338 (-443,-233)) compartments and percentage per annum loss in the lateral compartment(β = -0.15 (-0.29, -0.01)). Baseline JSN and osteophytes were associated with cartilage volume loss in the univariable analysis, however these associations did not persist after adjustment for other structural co-pathologies.
Cross-sectional cartilage volume measurement independently predicts cartilage volume loss over 10 years and can be used to identify fast progressors in clinical trials. Radiographic JSN and osteophytes on the other hand are a reflection of other co-pathologies assessed on MRI and do not independently predict cartilage volume loss over 10 years.
本研究旨在探讨通过MRI测量的软骨体积和基线时的放射学骨关节炎（OA）是否能相互独立以及独立于其他结构共同病变预测十年间的软骨体积损失。
对219名参与者[平均年龄45（26 - 61）岁；57%为女性]进行了基线和十年后的研究。大约一半是因OA接受膝关节置换术患者的成年后代，其余为随机选择的对照组。通过X线片评估关节间隙变窄（JSN）和骨赘，通过MRI评估软骨体积（胫股关节）、软骨缺损、骨髓病变和半月板撕裂/挤出。
内侧间室平均每年的绝对软骨体积损失和百分比损失分别为1284mm³和1.91%，外侧间室分别为1007mm³和1.38%。较高的基线胫股关节软骨体积与内侧（β（95%CI）=-300（-399，-200））和外侧（β=-338（-443，-233））间室更大的绝对软骨体积损失以及外侧间室每年的百分比损失（β=-0.15（-0.29，-0.01））独立相关。基线JSN和骨赘在单变量分析中与软骨体积损失相关，然而在调整其他结构共同病变后，这些关联不再持续。
横断面软骨体积测量可独立预测10年间的软骨体积损失，可用于在临床试验中识别快速进展者。另一方面，放射学JSN和骨赘是MRI评估的其他共同病变的反映，不能独立预测10年间的软骨体积损失。
