雷特格韦在体外人胎盘小叶灌注模型中的双向转运
Bidirectional Transfer of Raltegravir in an Ex Vivo Human Cotyledon Perfusion Model.
作者信息
Vinot Cécile, Tréluyer Jean-Marc, Giraud Carole, Gavard Laurent, Peytavin Gilles, Mandelbrot Laurent
机构信息
EA 3620, Université Paris Descartes, Paris, France Unité de Recherche Clinique Cochin Necker/CIC 0901, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France Risk in Pregnancy University Department, Paris, France.
EA 3620, Université Paris Descartes, Paris, France Unité de Recherche Clinique Cochin Necker/CIC 0901, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France Risk in Pregnancy University Department, Paris, France Service de Pharmacologie Clinique, Hôpitaux Universitaires Paris Centre Cochin-Broca-Hôtel Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France.
出版信息
Antimicrob Agents Chemother. 2016 Apr 22;60(5):3112-4. doi: 10.1128/AAC.00007-16. Print 2016 May.
Placental transfer of the HIV integrase inhibitor raltegravir (RLT) was investigated in term human cotyledons in the maternal-to-fetal (n = 3) and fetal-to-maternal (n = 6) directions. In the maternal-to-fetal direction, the mean ± standard deviation (SD) fetal transfer rate (FTR) was 9.1% ± 1.4%, and the mean ± SD clearance index (IC), i.e., RLT FTR/antipyrine FTR, was 0.28 ± 0.05. In the fetal-to-maternal direction, the mean ± SD CI was 0.31 ± 0.09. Placental transfer of RLT was high in both directions.
在足月人胎盘小叶中，研究了HIV整合酶抑制剂拉替拉韦（RLT）在母胎（n = 3）和胎母（n = 6）方向上的胎盘转运情况。在母胎方向上，平均±标准差（SD）的胎儿转运率（FTR）为9.1%±1.4%，平均±SD清除指数（IC），即RLT FTR/安替比林FTR为0.28±0.05。在胎母方向上，平均±SD CI为0.31±0.09。RLT在两个方向上的胎盘转运率都很高。
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