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The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Nat Commun. 2016 Feb 1;7:10495. doi: 10.1038/ncomms10495.
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
为了增进我们对肥胖的遗传基础及其与心血管代谢疾病风险之间联系的理解，我们对多达100716名个体的体脂百分比（BF%）进行了全基因组关联荟萃分析。12个位点达到全基因组显著性水平（P<5×10⁻⁸），其中8个位点先前与总体肥胖增加（BMI、BF%）相关，4个位点（在COBLL1/GRB14、IGF2BP1、PLA2G6、CRTC1内部或附近）是与BF%的新关联。7个位点对BF%的影响大于对BMI的影响，提示与肥胖存在主要关联，而5个位点对BMI的影响大于对BF%的影响，表明与脂肪量和瘦体重均有关联。特别是，与BF%关联更强的位点显示出与一系列心血管代谢特征的独特跨表型关联特征，揭示了肥胖与疾病风险之间联系的新见解。
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