El-Sayed Refat, Althagafi Ismail
Chemistry Department, College of Applied Sciences, Umm Al-Qura University.
J Oleo Sci. 2016;65(2):177-92. doi: 10.5650/jos.ess15193.
Some functionalized pyridine and fused system derivatives were synthesized using enaminonitrile derivative 5 as a starting material for the reaction, with various reagents under different conditions. Propoxylation of these compounds using different moles of propylene oxide (3, 5 and 7 moles) leads to a novel group of surface active agents. The antimicrobial and surface activities of the synthesized compounds were investigated. Most of the evaluated compounds proved to be active as antibacterial and antifungal agents and showed good surface activity, which makes them suitable for diverse applications such as the manufacturing of emulsifiers, cosmetics, drugs, pesticides, etc. Additionally, biodegradation testing exhibits significant breakdown within six to seven days, and hence, lowers the toxicity to human beings and becomes environmentally friendly.
以烯胺腈衍生物5为反应起始原料，在不同条件下与各种试剂反应，合成了一些功能化吡啶及稠合体系衍生物。使用不同摩尔数的环氧丙烷（3、5和7摩尔）对这些化合物进行丙氧基化反应，得到了一组新型表面活性剂。对合成化合物的抗菌和表面活性进行了研究。大多数评估化合物被证明具有抗菌和抗真菌活性，并表现出良好的表面活性，这使其适用于多种应用，如制造乳化剂、化妆品、药物、农药等。此外，生物降解测试表明，这些化合物在六到七天内会有显著分解，因此降低了对人类的毒性，变得对环境友好。
