胰岛素样生长因子1对胎儿和早产儿发育具有多系统效应。
Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development.
作者信息
Hellström Ann, Ley David, Hansen-Pupp Ingrid, Hallberg Boubou, Löfqvist Chatarina, van Marter Linda, van Weissenbruch Mirjam, Ramenghi Luca A, Beardsall Kathryn, Dunger David, Hård Anna-Lena, Smith Lois E H
机构信息
Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Pediatrics, Institute of Clinical Sciences Lund, Skane University Hospital, Lund University, Lund, Sweden.
出版信息
Acta Paediatr. 2016 Jun;105(6):576-86. doi: 10.1111/apa.13350. Epub 2016 Mar 8.
UNLABELLED
Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.
CONCLUSION
There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.
未标注
早产产后生长不良与子宫内正常的快速生长不匹配，且与早产并发症相关。胰岛素样生长因子1（IGF-1）轴是子宫内生长的主要激素调节因子，早产出生后IGF-1水平通常非常低。我们回顾了IGF-1在胎儿发育及相应早产围产期的作用，以突出IGF-1缺乏在早产并发症中的潜在临床重要性。
结论
有理由开展临床试验，以评估IGF-1替代疗法对极早早产儿的潜在益处。
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