• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

胰岛素样生长因子1对胎儿和早产儿发育具有多系统效应。

Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development.

作者信息

Hellström Ann, Ley David, Hansen-Pupp Ingrid, Hallberg Boubou, Löfqvist Chatarina, van Marter Linda, van Weissenbruch Mirjam, Ramenghi Luca A, Beardsall Kathryn, Dunger David, Hård Anna-Lena, Smith Lois E H

机构信息

Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Department of Pediatrics, Institute of Clinical Sciences Lund, Skane University Hospital, Lund University, Lund, Sweden.

出版信息

Acta Paediatr. 2016 Jun;105(6):576-86. doi: 10.1111/apa.13350. Epub 2016 Mar 8.

DOI:10.1111/apa.13350
PMID:26833743
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5069563/
Abstract

UNLABELLED

Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.

CONCLUSION

There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.

摘要

未标注

早产产后生长不良与子宫内正常的快速生长不匹配，且与早产并发症相关。胰岛素样生长因子1（IGF-1）轴是子宫内生长的主要激素调节因子，早产出生后IGF-1水平通常非常低。我们回顾了IGF-1在胎儿发育及相应早产围产期的作用，以突出IGF-1缺乏在早产并发症中的潜在临床重要性。

结论

有理由开展临床试验，以评估IGF-1替代疗法对极早早产儿的潜在益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/bcdbd792cebd/APA-105-576-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/89c252e33ee4/APA-105-576-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/8c2a0fecf4de/APA-105-576-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/a40f27a83344/APA-105-576-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/5570d7653ecd/APA-105-576-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/8fb2ff22608d/APA-105-576-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/9e53834f1287/APA-105-576-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/bcdbd792cebd/APA-105-576-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/89c252e33ee4/APA-105-576-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/8c2a0fecf4de/APA-105-576-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/a40f27a83344/APA-105-576-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/5570d7653ecd/APA-105-576-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/8fb2ff22608d/APA-105-576-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/9e53834f1287/APA-105-576-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f5b/5069563/bcdbd792cebd/APA-105-576-g007.jpg

相似文献

1
Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development.胰岛素样生长因子1对胎儿和早产儿发育具有多系统效应。
Acta Paediatr. 2016 Jun;105(6):576-86. doi: 10.1111/apa.13350. Epub 2016 Mar 8.
2
Role of Insulinlike Growth Factor 1 in Fetal Development and in the Early Postnatal Life of Premature Infants.胰岛素样生长因子1在胎儿发育及早产儿出生后早期生活中的作用。
Am J Perinatol. 2016 Sep;33(11):1067-71. doi: 10.1055/s-0036-1586109. Epub 2016 Sep 7.
3
Serum insulin-like growth factor I (IGF-I), IGF-binding proteins-1 and -3, and postnatal growth of late preterm infants.血清胰岛素样生长因子 I (IGF-I)、IGF 结合蛋白-1 和 -3 与晚期早产儿的出生后生长。
Horm Metab Res. 2012 Oct;44(11):845-50. doi: 10.1055/s-0032-1321759. Epub 2012 Jul 12.
4
Physical growth and retinopathy in preterm infants: involvement of IGF-I and GH.早产儿的身体生长与视网膜病变：胰岛素样生长因子-I和生长激素的作用
Pediatr Res. 2001 Dec;50(6):732-6. doi: 10.1203/00006450-200112000-00017.
5
Growth in preterm infants until six months postterm: the role of insulin and IGF-I.早产儿直至校正后 6 月龄时的生长：胰岛素和 IGF-I 的作用。
Horm Res Paediatr. 2013;80(2):92-9. doi: 10.1159/000351710. Epub 2013 Jun 29.
6
Postnatal decrease in circulating insulin-like growth factor-I and low brain volumes in very preterm infants.早产儿出生后循环胰岛素样生长因子-I 减少与脑体积小。
J Clin Endocrinol Metab. 2011 Apr;96(4):1129-35. doi: 10.1210/jc.2010-2440. Epub 2011 Feb 2.
7
Changes in serum insulin-like growth factors, not leptin, are associated with postnatal weight gain in preterm neonates.血清胰岛素样生长因子而非瘦素的变化与早产儿出生后的体重增加有关。
JPEN J Parenter Enteral Nutr. 2005 Mar-Apr;29(2):87-92. doi: 10.1177/014860710502900287.
8
Dietary proteins and IGF I levels in preterm infants: determinants of growth, body composition, and neurodevelopment.早产儿的膳食蛋白质与胰岛素样生长因子I水平：生长、身体成分及神经发育的决定因素
Pediatr Res. 2015 Jan;77(1-2):156-63. doi: 10.1038/pr.2014.172. Epub 2014 Oct 21.
9
Inflammation at birth and the insulin-like growth factor system in very preterm infants.极早产儿出生时的炎症与胰岛素样生长因子系统
Acta Paediatr. 2007 Jun;96(6):830-6. doi: 10.1111/j.1651-2227.2007.00276.x. Epub 2007 Apr 27.
10
The role of maternal factors, postnatal nutrition, weight gain, and gender in regulation of serum IGF-I among preterm infants.母亲因素、产后营养、体重增加及性别在早产儿血清胰岛素样生长因子-I调节中的作用。
Pediatr Res. 2005 Apr;57(4):605-10. doi: 10.1203/01.PDR.0000155950.67503.BC. Epub 2005 Feb 4.

引用本文的文献

1
Association of early postnatal decline in fetal hemoglobin with bronchopulmonary dysplasia in very low birth weight infants: a cohort study.极低出生体重儿出生后早期胎儿血红蛋白下降与支气管肺发育不良的关联：一项队列研究
BMC Pregnancy Childbirth. 2025 Aug 19;25(1):864. doi: 10.1186/s12884-025-07945-x.
2
Association of Cord Blood Metabolic Biomarkers (Leptin, Adiponectin, IGF-1) with Fetal Adiposity Across Gestation.脐带血代谢生物标志物（瘦素、脂联素、胰岛素样生长因子-1）与整个孕期胎儿肥胖的关联。
Int J Mol Sci. 2025 Jul 18;26(14):6926. doi: 10.3390/ijms26146926.
3
Expert review of CLABSI prevention in the NICU: supporting the transition of investigational drugs into clinical practice.

本文引用的文献

1
IGF-II expression and methylation in small for gestational age infants.小于胎龄儿中胰岛素样生长因子-II的表达与甲基化
J Pediatr Endocrinol Metab. 2015 May;28(5-6):613-8. doi: 10.1515/jpem-2014-0269.
2
Growth factors and metabolic markers in cord blood: relationship to birth weight and length.脐带血中的生长因子和代谢标志物：与出生体重和身长的关系。
J Biol Regul Homeost Agents. 2014 Apr-Jun;28(2):237-49.
3
In utero fuel homeostasis: Lessons for a clinician.子宫内的燃料稳态：给临床医生的启示。
新生儿重症监护病房中心静脉导管相关血流感染预防的专家评审：支持研究性药物向临床实践的转化。
Eur J Pediatr. 2025 Jul 19;184(8):492. doi: 10.1007/s00431-025-06329-9.
4
Comparison of the effectiveness of recombinant human growth hormone therapy in preterm and full-term children with short stature born small for gestational age.重组人生长激素治疗对小于胎龄儿早产和足月身材矮小儿童有效性的比较。
Ann Pediatr Endocrinol Metab. 2025 Jun;30(3):140-148. doi: 10.6065/apem.2448128.064. Epub 2025 Jun 30.
5
Cord blood levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 correlate with perinatal brain development in fetal congenital heart disease.胎儿先天性心脏病中，脐血胰岛素样生长因子-1和胰岛素样生长因子结合蛋白-3水平与围产期脑发育相关。
Ultrasound Obstet Gynecol. 2025 Aug;66(2):200-209. doi: 10.1002/uog.29271. Epub 2025 Jun 28.
6
Evaluating Prevalence of Preterm Postnatal Growth Faltering Using Fenton 2013 and INTERGROWTH-21st Growth Charts with Logistic and Machine Learning Models.使用Fenton 2013生长曲线和INTERGROWTH-21st生长曲线以及逻辑回归和机器学习模型评估早产产后生长迟缓的患病率。
Nutrients. 2025 May 20;17(10):1726. doi: 10.3390/nu17101726.
7
Plasma amino acids after human milk fortification and associations with growth in preterm infants.人乳强化后早产儿的血浆氨基酸及其与生长的关系。
Pediatr Res. 2025 May 18. doi: 10.1038/s41390-025-04126-6.
8
Retinopathy of Prematurity (ROP): An Overview of Biomarkers in Various Samples for Prediction, Diagnosis, and Prognosis.早产儿视网膜病变（ROP）：用于预测、诊断和预后的各种样本中生物标志物概述
Clin Ophthalmol. 2025 May 7;19:1515-1530. doi: 10.2147/OPTH.S519292. eCollection 2025.
9
Prolonged Parenteral Nutrition Increases the Risk of Comorbidities in Very-Low-Birth-Weight Infants: A Prospective National Cohort Study in South Korea.长期肠外营养增加极低出生体重儿合并症风险：韩国一项前瞻性全国队列研究
Nutrients. 2025 Mar 12;17(6):996. doi: 10.3390/nu17060996.
10
Association of Neonatal Morbidities and Postnatal Growth Faltering in Preterm Neonates.早产儿的新生儿发病率与出生后生长发育迟缓的关联
Healthcare (Basel). 2025 Jan 24;13(3):235. doi: 10.3390/healthcare13030235.
Indian J Endocrinol Metab. 2013 Jan;17(1):60-8. doi: 10.4103/2230-8210.107851.
4
Endocrine control of growth.内分泌对生长的控制。
Am J Med Genet C Semin Med Genet. 2013 May;163C(2):76-85. doi: 10.1002/ajmg.c.31357.
5
Insulin resistance: an adaptive mechanism becomes maladaptive in the current environment - an evolutionary perspective.胰岛素抵抗：在当前环境下，适应性机制变得适应不良——从进化角度看。
Metabolism. 2013 May;62(5):622-33. doi: 10.1016/j.metabol.2012.11.004. Epub 2012 Dec 20.
6
Neurodevelopmental effects of insulin-like growth factor signaling.胰岛素样生长因子信号对神经发育的影响。
Front Neuroendocrinol. 2012 Aug;33(3):230-51. doi: 10.1016/j.yfrne.2012.06.002. Epub 2012 Jun 16.
7
Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue.胎儿白色脂肪组织中脂肪酸的胎龄依赖性含量、组成和宫内积累率。
Prostaglandins Leukot Essent Fatty Acids. 2012 Jan-Feb;86(1-2):39-49. doi: 10.1016/j.plefa.2011.10.007. Epub 2011 Nov 16.
8
IGF1 molecular anomalies demonstrate its critical role in fetal, postnatal growth and brain development.IGF1 分子异常表明其在胎儿、出生后生长和大脑发育中具有关键作用。
Best Pract Res Clin Endocrinol Metab. 2011 Feb;25(1):181-90. doi: 10.1016/j.beem.2010.08.005.
9
Partial primary deficiency of insulin-like growth factor (IGF)-I activity associated with IGF1 mutation demonstrates its critical role in growth and brain development.与IGF1突变相关的胰岛素样生长因子（IGF）-I活性部分原发性缺乏证明了其在生长和大脑发育中的关键作用。
J Clin Endocrinol Metab. 2009 Oct;94(10):3913-21. doi: 10.1210/jc.2009-0452. Epub 2009 Sep 22.
10
The hormonal action of IGF1 in postnatal mouse growth.胰岛素样生长因子1（IGF1）在出生后小鼠生长中的激素作用。
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19378-83. doi: 10.1073/pnas.0809223105. Epub 2008 Nov 25.