身体活动减弱了基因对体重指数的影响：一项中国成年双胞胎研究的结果

Physical activity attenuates genetic effects on BMI: Results from a study of Chinese adult twins.

作者信息

Wang Biqi, Gao Wenjing, Lv Jun, Yu Canqing, Wang Shengfeng, Pang Zengchang, Cong Liming, Dong Zhong, Wu Fan, Wang Hua, Wu Xianping, Jiang Guohong, Wang Xiaojie, Wang Binyou, Cao Weihua, Li Liming

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Qingdao Center for Diseases Control and Prevention, Qingdao, China.

出版信息

Obesity (Silver Spring). 2016 Mar;24(3):750-6. doi: 10.1002/oby.21402. Epub 2016 Feb 2.

DOI:10.1002/oby.21402

PMID:26833823

Abstract

OBJECTIVE

This study aimed to examine the gene-environment interaction of physical activity and body mass index (BMI) using the Chinese National Twin Registry (CNTR).

METHODS

A total of 19,308 same-sex adult twins from CNTR were included in the analysis. Twin zygosity was determined by self-reported questionnaire. Height and weight were measured using self-reported questionnaire. The vigorous physical activity was defined as greater or equal to five times a week of at least 30 min moderate- or high-intensity physical activity. A twin structural equation model was used to analyze the gene-environment interaction of vigorous exercise with BMI among 13,506 monozygotic twins and 5,802 dizygotic twins.

RESULTS

A structural equation model adjusting for age and sex found vigorous exercise significantly moderated the additive genetic effects (P < 0.001) and shared environmental effects (P < 0.001) on BMI. The genetic contributions to BMI were significantly lower for people who adopted a physically active lifestyle [h(2) = 40%, 95% confidence interval (CI): 35%-46%] than those who were relative sedentary (h(2) = 59%, 95% CI: 52%-66%). The observed gene-physical activity interaction was more pronounced in men than women.

CONCLUSIONS

Our results suggested that adopting a physically active lifestyle may help to reduce the genetic influence on BMI among the Chinese population.

摘要

目的

本研究旨在利用中国国家双胞胎登记处（CNTR）探讨身体活动与体重指数（BMI）之间的基因 - 环境相互作用。

方法

分析纳入了来自CNTR的总共19308对同性成年双胞胎。通过自我报告问卷确定双胞胎的合子性。使用自我报告问卷测量身高和体重。剧烈身体活动定义为每周至少进行5次、每次至少30分钟的中等强度或高强度身体活动。采用双胞胎结构方程模型分析13506对同卵双胞胎和5802对异卵双胞胎中剧烈运动与BMI之间的基因 - 环境相互作用。

结果

一个调整了年龄和性别的结构方程模型发现，剧烈运动显著调节了对BMI的加性遗传效应（P < 0.001）和共享环境效应（P < 0.001）。采用积极生活方式的人对BMI的遗传贡献[h(2) = 40%，95%置信区间（CI）：35% - 46%]显著低于相对久坐的人（h(2) = 59%，95% CI：52% - 66%）。观察到的基因 - 身体活动相互作用在男性中比女性中更明显。