中国国家双胞胎登记处：复杂疾病系统流行病学的独特数据源。
The Chinese National Twin Registry: A Unique Data Source for Systems Epidemiology of Complex Disease.
作者信息
Huang Tao, Gao Wenjing, Lv Jun, Yu Canqing, Wu Tao, Wang Shengfeng, Liao Chunxiao, Meng Lu, Wang Dongmeng, Wang Zhaonian, Pang Zengchang, Yu Min, Wang Hua, Wu Xianping, Dong Zhong, Wu Fan, Jiang Guohong, Wang Xiaojie, Liu Yu, Deng Jian, Lu Lin, Cao Weihua, Li Liming
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Qingdao Center for Disease Control and Prevention, Qingdao, China.
出版信息
Twin Res Hum Genet. 2019 Dec;22(6):482-485. doi: 10.1017/thg.2019.85. Epub 2019 Nov 11.
The Chinese National Twin Registry (CNTR), initiated in 2001, has now become the largest twin registry in Asia. From 2015 to 2018, the CNTR continued to receive Chinese government funding and had recruited 61,566 twin-pairs by 2019 to study twins discordant for specific exposures such as environmental factors, and twins discordant for disease outcomes or measures of morbidity. Omic data, including genetics, genomics, metabolomics, and proteomics, and gut microbiome will be tested. The integration of omics and digital technologies in public health will advance our understanding of precision public health. This review introduces the updates of the CNTR, including study design, sample size, biobank, zygosity assessment, advances in research and future systems epidemiologic research.
中国国家双胞胎登记处（CNTR）于2001年启动，现已成为亚洲最大的双胞胎登记处。2015年至2018年，CNTR继续获得中国政府资助，到2019年已招募了61566对双胞胎，以研究在特定暴露因素（如环境因素）上不一致的双胞胎，以及在疾病结局或发病率测量上不一致的双胞胎。将对包括遗传学、基因组学、代谢组学和蛋白质组学在内的组学数据以及肠道微生物群进行检测。组学和数字技术在公共卫生中的整合将推动我们对精准公共卫生的理解。本综述介绍了CNTR的最新情况，包括研究设计、样本量、生物样本库、合子性评估、研究进展以及未来的系统流行病学研究。
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