更高的咳嗽流量与急性中风中肺炎风险降低相关。

Higher cough flow is associated with lower risk of pneumonia in acute stroke.

机构信息

Faculty of Health, Social Care and Education, St George's, University of London, London, UK.

Division of Asthma, Allergy & Lung Biology, Faculty of Life Sciences and Medicine, King's College London, London, UK.

出版信息

Thorax. 2016 May;71(5):474-5. doi: 10.1136/thoraxjnl-2015-207810. Epub 2016 Feb 1.

DOI:10.1136/thoraxjnl-2015-207810

PMID:26834183

Abstract

UNLABELLED

There is little available evidence to demonstrate how cough strength mediates the risk of aspiration-related pneumonia in acute stroke. Our secondary analysis of trial data indicates that risk of pneumonia reduces with increasing peak cough flow (PCF) of voluntary cough (OR 0.994 for each 1 L/min increase in PCF, 95% CI 0.988 to 1.0, p=0.035); and to a lesser degree with increasing PCF of reflex cough (OR 0.998 for each 1 L/min increase in PCF, 95% CI 0.992 to 1.004, p=0.475). These data serve hypothesis generation. Further studies are needed to confirm these findings and validate their clinical utility.

CLINICAL TRIAL REGISTRATION NUMBER

ISRCTN40298220 (post-results).

摘要

目的：目前可用的证据很少能够证明咳嗽强度如何介导急性脑卒中患者与吸入相关肺炎的风险。我们对试验数据的二次分析表明，肺炎的风险随着自主咳嗽的最大咳嗽峰流速（PCF）的增加而降低（每增加 1L/min 的 PCF，OR 为 0.994，95%CI 为 0.988 至 1.0，p=0.035）；而随着反射性咳嗽的 PCF 增加，肺炎的风险降低程度较小（每增加 1L/min 的 PCF，OR 为 0.998，95%CI 为 0.992 至 1.004，p=0.475）。这些数据为假说的产生提供了依据。需要进一步的研究来证实这些发现并验证其临床实用性。

临床试验注册号：ISRCTN40298220（结果后）。