Kolb E
Wissenschaftsbereich Tierbiochemie, Karl-Marx-Universität Leipzig.
Z Gesamte Inn Med. 1989 Jul 15;44(14):405-9.
The interleukins play an important role as intensifying molecules in the activation of the immune system in infections and inflammation processes. Antigens are worked up by macrophages and B-lymphocytes, whereby partly develop particularly intensively antigen-effective compounds. The uptake of antigens in macrophages evokes the formation of interleukin 1 which has multivarious effects. The macrophages and the B-lymphocytes present the antigens worked up after uptake into the cell membrane to certain forms of T-lymphocytes which thus are stimulated to the formation of the interleukins 2 to 6. The interleukins 2 and 4 promote the increase of certain forms of T-lymphocytes and the formation of cytotoxically acting T-lymphocytes. The interleukin 3 is of importance for the increase of stem cells of the bone-marrow and for their differentiation. The interleukins 4, 5, and 6 promote the increase of certain B-lymphocytes. In the liver the interleukins 1 and 6 stimulate the formation of numerous proteins which have influence on inflammation processes.
白细胞介素作为强化分子在感染和炎症过程中免疫系统的激活中发挥重要作用。抗原由巨噬细胞和B淋巴细胞处理，由此部分会特别强烈地产生具有抗原效应的化合物。巨噬细胞摄取抗原会引发白细胞介素1的形成，其具有多种作用。巨噬细胞和B淋巴细胞将摄取后处理过的抗原呈递到细胞膜上给某些形式的T淋巴细胞，从而刺激这些T淋巴细胞形成白细胞介素2至6。白细胞介素2和4促进某些形式的T淋巴细胞的增加以及细胞毒性作用的T淋巴细胞的形成。白细胞介素3对于骨髓干细胞的增加及其分化很重要。白细胞介素4、5和6促进某些B淋巴细胞的增加。在肝脏中，白细胞介素1和6刺激许多对炎症过程有影响的蛋白质的形成。
