State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China.
Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Cancer Biomark. 2016;16(1):71-9. doi: 10.3233/CBM-150542.
The Hedgehog (Hh) signaling pathway has recently been reported to be associated with the prognosis of digestive system cancers. However, the results are inconsistent.
This study aimed to investigate the association between Hh pathway components and survival outcomes in patients with digestive system cancers.
We conducted a comprehensive retrieval in PubMed, EMBASE and Cochrane library for relevant literatures until May 1st, 2015. The pooled hazard ratios (HRs) for overall survival (OS) and disease-free survival (DFS) with 95% confidence intervals (CIs) were calculated to clarify the prognostic value of Hh pathway components, including Shh, Gli1, Gli2, Smo and Ptch1.
A total of 16 eligible articles with 3222 patients were included in the meta-analysis. Pooled HR suggested that over-expression of Shh and Gli1 were both associated with poor OS (HR = 1.87, 95% CI: 1.14-3.07 and HR = 1.96, 95% CI: 1.66-2.32, respectively) and DFS (HR = 2.37, 95% CI: 1.19-4.72 and HR = 2.18, 95% CI: 1.61-2.96, respectively). In addition, over-expression of Smo was associated with poor DFS (HR = 1.38, 95% CI: 1.08-1.75).
This study reveals that over-expressed Hh pathway components, including Shh, Gli1 and Smo, are associated with poor prognosis in digestive system cancer patients. Hh signaling pathway may become a potential therapeutic target in digestive system cancers.
Hedgehog（Hh）信号通路最近被报道与消化系统癌症的预后相关。然而，结果并不一致。
本研究旨在探讨 Hh 通路成分与消化系统癌症患者生存结局的关系。
我们在 PubMed、EMBASE 和 Cochrane 图书馆中进行了全面检索，检索截至 2015 年 5 月 1 日的相关文献。采用合并风险比（HR）及其 95%置信区间（CI）来评估总体生存（OS）和无病生存（DFS）的预后价值，Hh 通路成分包括 Shh、Gli1、Gli2、Smo 和 Ptch1。
共有 16 项符合条件的研究，共计 3222 例患者纳入荟萃分析。合并 HR 提示，Shh 和 Gli1 过表达均与较差的 OS（HR=1.87，95%CI：1.14-3.07 和 HR=1.96，95%CI：1.66-2.32）和 DFS（HR=2.37，95%CI：1.19-4.72 和 HR=2.18，95%CI：1.61-2.96）相关。此外，Smo 过表达与较差的 DFS 相关（HR=1.38，95%CI：1.08-1.75）。
本研究揭示了 Hh 通路成分，包括 Shh、Gli1 和 Smo 的过表达与消化系统癌症患者的不良预后相关。Hh 信号通路可能成为消化系统癌症的潜在治疗靶点。
