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Med Monatsschr Pharm. 2015 Dec;38(12):484-8.
Whooping cough is a highly contagious respiratory disease which is caused predominantly by the gram-negative bacterium Bordetella pertussis. Further Bordetella species such as B. parapertussis and the recently discovered species B. holmesii are also involved in whooping cough-like diseases. Depending on age, vaccination status and distance to pre-infection with B. pertussis, whooping cough shows a wide range of symptoms. The disease occurs at any age, leaving only short time immunity. During the last 15 years, in industrialized countries the number of reported pertussis cases has been increased markedly. The reason for this observation is still unclear Macrolides such as azithromycin and clarithromycin are regarded as antibiotics of first choice. In Germany, combination vaccines containing acellular pertussis vaccines is the most important strategy of prevention. To ensure the best possible protection against pertussis, booster doses at determined times should be given after primary vaccination in infancy.
百日咳是一种高度传染性的呼吸道疾病，主要由革兰氏阴性菌百日咳博德特氏菌引起。其他博德特氏菌属物种，如副百日咳博德特氏菌和最近发现的霍氏博德特氏菌，也与百日咳样疾病有关。根据年龄、疫苗接种状况以及与百日咳博德特氏菌初次感染的时间间隔，百日咳会表现出广泛的症状。该疾病可发生于任何年龄，免疫期较短。在过去15年中，工业化国家报告的百日咳病例数显著增加。这一现象的原因仍不清楚。阿奇霉素和克拉霉素等大环内酯类药物被视为首选抗生素。在德国，含有无细胞百日咳疫苗的联合疫苗是最重要的预防策略。为确保对百日咳提供尽可能好的保护，婴儿期初次接种疫苗后应在特定时间给予加强剂量。
