成人甘露糖结合凝集素缺乏与反复感染易感性
Mannose-binding lectin deficiency and predisposition to recurrent infection in adults.
作者信息
Holdaway Jenny, Deacock Sarah, Williams Peter, Karim Yousuf
机构信息
Immunology Department, Ashford and St Peter's Hospitals NHS Foundation Trust, Chertsey, UK.
Department of Mathematics, University of Surrey, Guildford, UK.
出版信息
J Clin Pathol. 2016 Aug;69(8):731-6. doi: 10.1136/jclinpath-2015-203065. Epub 2016 Feb 2.
AIMS
The effects of mannose-binding lectin (MBL) deficiency are well known in children and in those with a compromised immune system. However, its effects in adults are debateable, with little research having been carried out in the UK regarding infection risk in otherwise healthy adults with an MBL deficiency.
METHODS
Using an ELISA, we investigated the prevalence of MBL deficiency in both healthy adults and those with recurrent infection. The aim was to determine first if there was a disparity in MBL levels between the two groups and second to investigate the effect of severe deficiency.
RESULTS
Overall, the difference between the two groups for MBL level was found not to be statistically significant (p=0.203); however, there was a higher prevalence of severe deficiency (MBL<75 ng/mL) in the patients with recurrent infection (p=0.03).
CONCLUSIONS
It was concluded that there is justified reason for continuing to perform the MBL test in adult patients suffering recurrent infection.
目的
甘露糖结合凝集素（MBL）缺乏症在儿童和免疫系统受损者中的影响已为人熟知。然而，其在成人中的影响存在争议，在英国，针对MBL缺乏的健康成人感染风险的研究较少。
方法
我们使用酶联免疫吸附测定法（ELISA），调查了健康成人和反复感染者中MBL缺乏症的患病率。目的首先是确定两组之间MBL水平是否存在差异，其次是研究严重缺乏的影响。
结果
总体而言，发现两组之间的MBL水平差异无统计学意义（p = 0.203）；然而，反复感染患者中严重缺乏（MBL<75 ng/mL）的患病率更高（p = 0.03）。
结论
得出的结论是，对于反复感染的成年患者继续进行MBL检测是有充分理由的。
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