肿瘤肾切除标本中的非肿瘤性病理学

Non-neoplastic Pathology in Tumor Nephrectomy Specimens.

作者信息

Bijol Vanesa, Batal Ibrahim

机构信息

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

出版信息

Surg Pathol Clin. 2014 Sep;7(3):291-305. doi: 10.1016/j.path.2014.04.001. Epub 2014 Jun 26.

DOI:10.1016/j.path.2014.04.001

PMID:26837441

Abstract

Risk factors for kidney cancers and medical kidney diseases are similar; therefore, it is not surprising that up to 25% of renal cell carcinoma patients have chronic kidney disease prior to nephrectomy and a significant number of patients with normal prenephrectomy renal function markers progress to chronic kidney disease over time. Evaluation of non-neoplastic parenchyma in tumor nephrectomy specimens can identify patients at risk for progression to chronic kidney disease, which is a critical step for early intervention and potential improvement of morbidity and mortality rates in this patient population.

摘要

肾癌和医学性肾脏疾病的风险因素相似；因此，不足为奇的是，高达25%的肾细胞癌患者在肾切除术前就患有慢性肾病，并且大量术前肾功能指标正常的患者随着时间推移会发展为慢性肾病。评估肿瘤肾切除标本中的非肿瘤性实质可以识别有进展为慢性肾病风险的患者，这是对该患者群体进行早期干预并可能改善发病率和死亡率的关键一步。