肾移植中慢性移植肾失功的遗传学与表观遗传学

Genetics and Epigenetics of Chronic Allograft Dysfunction in Kidney Transplants.

作者信息

Zununi Vahed Sepideh, Samadi Nasser, Mostafidi Elmira, Ardalan Mohammad Reza, Omidi Yadollah

机构信息

Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Iran J Kidney Dis. 2016 Jan;10(1):1-9.

PMID:26837673

Abstract

Chronic allograft dysfunction is the most common cause of allograft lost. Chronic allograft dysfunction happens as a result of complex interactions at the molecular and cellular levels. Genetic and environmental factors both influence the evolution and progression of the chronic allograft dysfunction. Epigenetic modification could be considered as a therapeutically modifiable element to pause the fibrosis process through novel strategies. In this review, the PubMed database was searched for English-language articles on these new areas.

摘要

慢性移植器官功能障碍是移植器官丧失的最常见原因。慢性移植器官功能障碍是分子和细胞水平复杂相互作用的结果。遗传和环境因素都会影响慢性移植器官功能障碍的演变和进展。表观遗传修饰可被视为一种可通过新策略暂停纤维化进程的治疗性可调节因素。在本综述中，我们在PubMed数据库中搜索了关于这些新领域的英文文章。