Simpson Jean F, Boulos Fouad I
Department of Pathology, Vanderbilt University Medical Center, C-3318 Medical Center North, Nashville, TN 37232, USA.
Department of Pathology, American University, Beirut, Lebanon.
Surg Pathol Clin. 2009 Jun;2(2):235-46. doi: 10.1016/j.path.2009.02.002. Epub 2009 Jun 2.
The correct diagnosis of proliferations within the mammary terminal duct-lobular unit has paramount prognostic and therapeutic implications. Occasionally, the differential diagnosis of compact florid hyperplasia, atypical ductal hyperplasia, and low-grade ductal carcinoma in situ can be quite challenging, with seeming morphologic overlap. This article presents s conceptual and practical understanding of these processes and their impact on subsequent cancer risk, with the intention of assisting the practicing pathologist render accurate and clinically relevant diagnoses for this frequently encountered set of mammary epithelial lesions.
乳腺终末导管小叶单位内增生的正确诊断对预后和治疗具有至关重要的意义。偶尔，致密性小叶增生、非典型导管增生和低级别导管原位癌的鉴别诊断颇具挑战性，因为它们在形态学上存在明显重叠。本文介绍了对这些病变过程的概念性和实用性理解，以及它们对后续癌症风险的影响，旨在帮助病理科医生对这类常见的乳腺上皮病变做出准确且与临床相关的诊断。
