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慢性缺血性卒中的功能性康复与非功能性康复：一项随机功能磁共振成像研究的证据

Functional versus Nonfunctional Rehabilitation in Chronic Ischemic Stroke: Evidences from a Randomized Functional MRI Study.

作者信息

Pelicioni Maristela C X, Novaes Morgana M, Peres Andre S C, Lino de Souza Altay A, Minelli Cesar, Fabio Soraia R C, Pontes-Neto Octavio M, Santos Antonio C, de Araujo Draulio B

机构信息

Radiology Division, Department of Internal Medicine, Ribeirao Preto School of Medicine, University of Sao Paulo, 14049-900 Ribeirao Preto, SP, Brazil.

Brain Institute/Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, 59153-155 Natal, RN, Brazil.

出版信息

Neural Plast. 2016;2016:6353218. doi: 10.1155/2016/6353218. Epub 2015 Dec 28.

DOI:10.1155/2016/6353218
PMID:26839716
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4709724/
Abstract

Motor rehabilitation of stroke survivors may include functional and/or nonfunctional strategy. The present study aimed to compare the effect of these two rehabilitation strategies by means of clinical scales and functional Magnetic Resonance Imaging (fMRI). Twelve hemiparetic chronic stroke patients were selected. Patients were randomly assigned a nonfunctional (NFS) or functional (FS) rehabilitation scheme. Clinical scales (Fugl-Meyer, ARA test, and modified Barthel) and fMRI were applied at four moments: before rehabilitation (P1) and immediately after (P2), 1 month after (P3), and three months after (P4) the end of rehabilitation. The NFS group improved significantly and exclusively their Fugl-Meyer scores at P2, P3, and P4, when compared to P1. On the other hand, the FS group increased significantly in Fugl-Meyer at P2, when compared to P1, and also in their ARA and Barthel scores. fMRI inspection at the individual level revealed that both rehabilitation schemes most often led to decreased activation sparseness, decreased activity of contralesional M1, increased asymmetry of M1 activity to the ipsilesional side, decreased perilesional activity, and decreased SMA activity. Increased M1 asymmetry with rehabilitation was also confirmed by Lateralization Indexes. Our clinical analysis revealed subtle differences between FS and NFS.

摘要

中风幸存者的运动康复可能包括功能性和/或非功能性策略。本研究旨在通过临床量表和功能磁共振成像（fMRI）比较这两种康复策略的效果。选取了12名慢性偏瘫中风患者。患者被随机分配到非功能性（NFS）或功能性（FS）康复方案。在四个时间点应用临床量表（Fugl-Meyer、ARA测试和改良Barthel指数）和fMRI：康复前（P1）、康复后立即（P2）、康复结束后1个月（P3）和康复结束后3个月（P4）。与P1相比，NFS组在P2、P3和P4时Fugl-Meyer评分显著且仅有所改善。另一方面，与P1相比，FS组在P2时Fugl-Meyer评分显著增加，其ARA和Barthel评分也增加。个体水平的fMRI检查显示，两种康复方案最常导致激活稀疏度降低、对侧M1活动降低、M1活动向患侧的不对称性增加、病灶周围活动降低以及辅助运动区活动降低。侧化指数也证实了康复后M1不对称性增加。我们的临床分析揭示了FS和NFS之间的细微差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/860d/4709724/d274bd8dfb14/NP2016-6353218.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/860d/4709724/9b4265a27661/NP2016-6353218.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/860d/4709724/5f3a26f1c68e/NP2016-6353218.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/860d/4709724/8b92ed282999/NP2016-6353218.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/860d/4709724/a58415e08419/NP2016-6353218.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/860d/4709724/d274bd8dfb14/NP2016-6353218.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/860d/4709724/9b4265a27661/NP2016-6353218.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/860d/4709724/5f3a26f1c68e/NP2016-6353218.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/860d/4709724/8b92ed282999/NP2016-6353218.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/860d/4709724/a58415e08419/NP2016-6353218.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/860d/4709724/d274bd8dfb14/NP2016-6353218.005.jpg

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本文引用的文献

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Neurorehabil Neural Repair. 2015 Sep;29(8):703-13. doi: 10.1177/1545968314562647. Epub 2014 Dec 19.
2
Beyond BOLD: optimizing functional imaging in stroke populations.超越血氧水平依赖性功能磁共振成像：优化中风人群的功能成像
Hum Brain Mapp. 2015 Apr;36(4):1620-36. doi: 10.1002/hbm.22711. Epub 2014 Dec 2.
3
Interhemispheric cerebral blood flow balance during recovery of motor hand function after ischemic stroke--a longitudinal MRI study using arterial spin labeling perfusion.
探索心脏相关慢性病患者功能性磁共振成像研究中不同样本的代表性：一项聚焦的系统评价。
Front Hum Neurosci. 2020 May 14;14:108. doi: 10.3389/fnhum.2020.00108. eCollection 2020.
4
Altered effective connectivity of resting state networks by acupuncture stimulation in stroke patients with left hemiplegia: A multivariate granger analysis.针刺刺激对左侧偏瘫中风患者静息态网络有效连接性的影响：多变量格兰杰分析
Medicine (Baltimore). 2017 Nov;96(47):e8897. doi: 10.1097/MD.0000000000008897.
5
Neural Patterns of Reorganization after Intensive Robot-Assisted Virtual Reality Therapy and Repetitive Task Practice in Patients with Chronic Stroke.慢性卒中患者强化机器人辅助虚拟现实治疗和重复任务练习后的神经重组模式
Front Neurol. 2017 Sep 4;8:452. doi: 10.3389/fneur.2017.00452. eCollection 2017.
6
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