Zachariéva S, Koev D, Tcharaktchiev D, Moskov M, Andonova K
Institut d'endocrinologie et gérontologie, Académie de médecine, Sofia, Bulgarie.
Ann Endocrinol (Paris). 1989;50(3):233-6.
The effect of captopril on the response of plasma aldosterone (PA) and plasma renin activity (PRA) to 10 mg metoclopramide i.v. was studied in 9 normal subjects. In the same conditions the prolactine response was studied in 6 healthy males. Metoclopramide induced a significant increase of PA during control study, as well as after treatment with captopril. The maximal increase of PA was of similar magnitude and occurred 15 mn after injection of metoclopramide on both occasions. PRA did not change appreciably after metoclopramide neither during control study nor during captopril. The prolactin response to metoclopramide was blunted by treatment with captopril. In conclusion, captopril did not alter the aldosterone response to metoclopramide, which suggests that dopaminergic control of aldosterone secretion is independent of modifications in the renin-angiotensin system.
在9名正常受试者中研究了卡托普利对静脉注射10毫克甲氧氯普胺后血浆醛固酮（PA）和血浆肾素活性（PRA）反应的影响。在相同条件下，对6名健康男性的催乳素反应进行了研究。在对照研究期间以及用卡托普利治疗后，甲氧氯普胺均引起PA显著增加。两次PA的最大增加幅度相似，均在注射甲氧氯普胺后15分钟出现。在对照研究期间和使用卡托普利期间，甲氧氯普胺后PRA均无明显变化。卡托普利治疗使催乳素对甲氧氯普胺的反应减弱。总之，卡托普利并未改变醛固酮对甲氧氯普胺的反应，这表明醛固酮分泌的多巴胺能控制独立于肾素-血管紧张素系统的改变。
