Lin Lizhou, Guo Lili, Zhang Weixing, Cai Xiaobo, Chen Dafan, Wan Xinjian
Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, People's Republic of China.
PLoS One. 2016 Feb 3;11(2):e0147701. doi: 10.1371/journal.pone.0147701. eCollection 2016.
125I seeds coated with titanium are considered a safe and effective interstitial brachytherapy for tumors, while the cost of 125I seeds is a major problem for the patients implanting lots of seeds. The aim of this paper was to develop a novel silicone coating for 125I seeds with a lower cost. In order to show the radionuclide utilization ratio, the silicone was coated onto the seeds using the electro-spinning method and the radioactivity was evaluated, then the anti-tumor efficacy of silicone 125I seeds was compared with titanium 125I seeds. The seeds were divided into four groups: A (control), B (pure silicone), C (silicone 125I), D (titanium 125I) at 2 Gy or 4 Gy. Their anti-tumour activity and mechanism were assessed in vitro and in vivo using a human extrahepatic cholangiocarcinoma cell line FRH-0201 and tumor-bearing BALB/c nude mice. The silicone 125I seeds showed higher radioactivity; the rate of cell apoptosis in vitro and the histopathology in vivo demonstrated that the silicone 125I seeds shared similar anti-tumor efficacy with the titanium 125I seeds for the treatment of extrahepatic cholangiocarcinoma, while they have a much lower cost.
涂有钛的¹²⁵I种子被认为是一种安全有效的肿瘤间质近距离放射治疗方法，然而¹²⁵I种子的成本对于植入大量种子的患者来说是一个主要问题。本文的目的是开发一种成本更低的¹²⁵I种子新型硅酮涂层。为了显示放射性核素利用率，采用静电纺丝法将硅酮涂覆在种子上并评估放射性，然后将硅酮¹²⁵I种子与钛¹²⁵I种子的抗肿瘤疗效进行比较。将种子分为四组：A（对照组）、B（纯硅酮组）、C（硅酮¹²⁵I组）、D（钛¹²⁵I组），剂量为2 Gy或4 Gy。使用人肝外胆管癌细胞系FRH - 0201和荷瘤BALB/c裸鼠在体外和体内评估它们的抗肿瘤活性和机制。硅酮¹²⁵I种子显示出更高的放射性；体外细胞凋亡率和体内组织病理学表明，硅酮¹²⁵I种子在治疗肝外胆管癌方面与钛¹²⁵I种子具有相似的抗肿瘤疗效，同时成本要低得多。
