通过立体保留实现基于钌的烯烃交叉复分解反应中的高反式动力学选择性。
High Trans Kinetic Selectivity in Ruthenium-Based Olefin Cross-Metathesis through Stereoretention.
机构信息
Materia, Inc., Pasadena, California 91107, United States.
The Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering. California Institute of Technology , Pasadena, California 91125, United States.
出版信息
Org Lett. 2016 Feb 19;18(4):772-5. doi: 10.1021/acs.orglett.6b00031. Epub 2016 Feb 3.
The first kinetically controlled, highly trans-selective (>98%) olefin cross-metathesis reaction is demonstrated using Ru-based catalysts. Reactions with either trans or cis olefins afford products with highly trans or cis stereochemistry, respectively. This E-selective olefin cross-metathesis is shown to occur between two trans olefins and between a trans olefin and a terminal olefin. Additionally, new stereoretentive catalysts have been synthesized for improved reactivity.
首次使用基于钌的催化剂实现了动力学控制的、高度反式选择性（>98%）的烯烃交叉复分解反应。与顺式或反式烯烃的反应分别得到具有高度反式或顺式立体化学的产物。这种 E-选择性烯烃交叉复分解反应发生在两个反式烯烃之间以及一个反式烯烃和一个末端烯烃之间。此外，还合成了新的立体保留性催化剂以提高反应活性。
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