二茂铁基烯烃的生物学评价：癌细胞生长抑制、活性氧生成及凋亡活性
Biological Evaluation of Ferrocenyl Olefins: Cancer Cell Growth Inhibition, ROS Production, and Apoptosis Activity.
作者信息
Sun Aijing, Lin Junsheng, Pi Chao, Xu Ruian, Cui Xiuling
机构信息
School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education, Quanzhou, P. R. China.
Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou, P. R. China.
出版信息
Arch Pharm (Weinheim). 2016 Mar;349(3):186-92. doi: 10.1002/ardp.201500314. Epub 2016 Feb 3.
The antiproliferative effects of various ferrocenyl olefins were evaluated against the cell lines MCF-7 (human breast cancer cells), DLD-1 (human colon adenocarcinoma cells), HUVEC (human umbilical vein endothelial cells), and A549 (human lung carcinoma cells), using the MTT test. IC50 values were determined. Compounds 8, 9, 11, and 12 with high antiproliferative activity were tested for their reactive oxygen species (ROS) production, and cell cycle analysis was performed on A549 cells. The results show that these compounds might perform their antiproliferative activity through inducing ROS generation, apoptosis induction, and cell cycle arrest.
使用MTT试验评估了各种二茂铁基烯烃对MCF-7（人乳腺癌细胞）、DLD-1（人结肠腺癌细胞）、HUVEC（人脐静脉内皮细胞）和A549（人肺癌细胞）细胞系的抗增殖作用。测定了IC50值。对具有高抗增殖活性的化合物8、9、11和12进行了活性氧（ROS）生成测试，并对A549细胞进行了细胞周期分析。结果表明，这些化合物可能通过诱导ROS生成、诱导凋亡和细胞周期阻滞来发挥其抗增殖活性。
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