Cadet J L, McCoy M T, Jayanthi S
Molecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.
Clin Pharmacol Ther. 2016 May;99(5):502-11. doi: 10.1002/cpt.345. Epub 2016 Feb 22.
Addictions are public health menaces. However, despite advances in addiction research, the cellular or molecular mechanisms that cause transition from recreational use to addiction remain to be elucidated. We have recently suggested that addiction may be secondary to long-term epigenetic modifications that determine the clinical course of substance use disorders. A better understanding of epigenetic mechanisms in animal models that mimic human conditions should help to usher in a new area of drug development against addiction.
成瘾是对公众健康的威胁。然而，尽管成瘾研究取得了进展，但导致从娱乐性使用转变为成瘾的细胞或分子机制仍有待阐明。我们最近提出，成瘾可能继发于长期的表观遗传修饰，这些修饰决定了物质使用障碍的临床病程。更好地理解模拟人类情况的动物模型中的表观遗传机制，应该有助于开创一个针对成瘾的药物开发新领域。
