酒精性肝炎：危险因素、发病机制及治疗方法
Alcoholic Hepatitis: Risk Factors, Pathogenesis, and Approach to Treatment.
作者信息
Yeluru Apurva, Cuthbert Jennifer A, Casey Lisa, Mitchell Mack C
机构信息
UT Southwestern Medical Center , Dallas, Texas.
Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas.
出版信息
Alcohol Clin Exp Res. 2016 Feb;40(2):246-55. doi: 10.1111/acer.12956.
BACKGROUND
Alcoholic hepatitis (AH) is an inflammatory disorder of the liver characterized clinically by jaundice, hepatomegaly, and abdominal pain, and histologically by macrovesicular steatosis and necroinflammation.
METHODS
This clinical review will cover what is known about the pathogenesis, clinical presentation, current treatments, and novel therapies for AH.
RESULTS
The pathogenesis and treatment of AH remain areas of active research. Although abstinence is the cornerstone of therapy for all stages of alcoholic liver disease, corticosteroids have shown modest short-term benefits in treatment of severe AH.
CONCLUSIONS
Improved understanding of the pathogenesis of AH has expanded the range of potential treatments for this devastating disease. Several novel therapies are also currently in various stages of testing through clinical trials.
背景
酒精性肝炎（AH）是一种肝脏炎症性疾病，临床特征为黄疸、肝肿大和腹痛，组织学特征为大泡性脂肪变性和坏死性炎症。
方法
本临床综述将涵盖关于AH的发病机制、临床表现、当前治疗方法和新疗法的已知信息。
结果
AH的发病机制和治疗仍是积极研究的领域。尽管戒酒是酒精性肝病所有阶段治疗的基石，但皮质类固醇在治疗重度AH方面已显示出适度的短期益处。
结论
对AH发病机制的深入了解扩大了这种毁灭性疾病的潜在治疗范围。目前也有几种新疗法正处于临床试验的不同阶段进行测试。
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