Wang W, Hallow K M, James D A
Novartis Pharmaceuticals East Hanover New Jersey USA.
University of Georgia Athens Georgia USA.
CPT Pharmacometrics Syst Pharmacol. 2016 Jan;5(1):3-10. doi: 10.1002/psp4.12052. Epub 2015 Dec 19.
This tutorial presents the application of an R package, RxODE, that facilitates quick, efficient simulations of ordinary differential equation models completely within R. Its application is illustrated through simulation of design decision effects on an adaptive dosing regimen. The package provides an efficient, versatile way to specify dosing scenarios and to perform simulation with variability with minimal custom coding. Models can be directly translated to Rshiny applications to facilitate interactive, real-time evaluation/iteration on simulation scenarios.
本教程介绍了一个R包RxODE的应用，该包有助于在R环境中完全快速、高效地模拟常微分方程模型。通过模拟设计决策对自适应给药方案的影响来说明其应用。该包提供了一种高效、通用的方法来指定给药方案，并以最少的自定义编码进行变异性模拟。模型可以直接转换为Rshiny应用程序，以便在模拟场景中进行交互式实时评估/迭代。
