Jirkovská A
Cas Lek Cesk. 1989 Sep 29;128(40):1249-53.
The review of new findings from the sphere of clinical, molecular genetic and physiological investigations is focused on the interpretation of the genetic transmission of type II diabetes, on possibilities of the early identification of relatives of diabetics liable to develop the disease and on the assessment of primary genetic defects. Associations of type II diabetes are sought in particular with polymorphism of the gene for insulin, insulin receptor and glucose transport. The author discusses also the problem of regulating genes and impaired dynamics of insulin secretion. The key problem of effective use of pretentious methods of genetic research is the selection of families of type II diabetics suitable for genealogical studies.
对临床、分子遗传学和生理学研究领域新发现的综述聚焦于Ⅱ型糖尿病的遗传传递解读、早期识别易患该病的糖尿病患者亲属的可能性以及原发性基因缺陷评估。尤其要探寻Ⅱ型糖尿病与胰岛素、胰岛素受体及葡萄糖转运基因多态性之间的关联。作者还讨论了基因调控问题以及胰岛素分泌动力学受损问题。有效运用先进基因研究方法的关键问题在于选择适合系谱研究的Ⅱ型糖尿病患者家族。
