根据博洛尼亚标准评估低反应者体外受精的预后：一项来自中国的大样本回顾性研究
The Prognosis of IVF in Poor Responders Depending on the Bologna Criteria: A Large Sample Retrospective Study from China.
作者信息
Yang Shuo, Chen Xinna, Zhen Xiumei, Wang Haiyan, Ma Caihong, Li Rong, Liu Ping, Qiao Jie
机构信息
Peking University Third Hospital, No. 49, North Huayuan Road, Haidian District, Beijing 100191, China.
出版信息
Biomed Res Int. 2015;2015:296173. doi: 10.1155/2015/296173. Epub 2015 Dec 30.
OBJECTIVE
To analyze the treatment outcomes of patients who accepted IVF/ICSI-ET, diagnosed POR according to Bologna criteria.
STUDY DESIGN
Retrospective cohort study of one reproductive medical center, from 1st Jan., 2009, to 31st Dec., 2014. All patients fulfilled the Bologna criteria and accept IVF/ICSI-ET treatment with stimulation cycle. The main outcome measures were clinical pregnancy rate (CPR) and live birth rate (LBR).
RESULTS
There were 5770 eligible cycles included in this study. The incidence of POR was 10.3% (6286/62194). The overall CPR was 18.7%, IR was 11.6%, LBR/ET was 11.5%, and LBR/OPU was 8.3%. The cycle cancellation for no available oocyte or embryo was 4.9% and 18.6%, respectively. The subgroup of younger POR patients got highest CPR and LBR/ET, which decreased while increasing maternal age. Within three attempts, the patients got similar CPR and LBR.
CONCLUSION
In conclusion, our study supports the Bologna criteria that defined women with poor IVF outcomes. But those younger than 42 years old with the first 3 attempts of IVF could got acceptable CPR and LBR.
目的
分析根据博洛尼亚标准诊断为卵巢反应不良（POR）并接受体外受精/卵胞浆内单精子注射-胚胎移植（IVF/ICSI-ET）的患者的治疗结局。
研究设计
对一家生殖医学中心2009年1月1日至2014年12月31日期间进行的回顾性队列研究。所有患者均符合博洛尼亚标准，并接受了刺激周期的IVF/ICSI-ET治疗。主要观察指标为临床妊娠率（CPR）和活产率（LBR）。
结果
本研究纳入了5770个符合条件的周期。POR的发生率为10.3%（628/62194）。总体CPR为18.7%，植入率（IR）为11.6%，胚胎移植后的LBR为11.5%，取卵后的LBR为8.3%。因无可用卵母细胞或胚胎而取消周期的比例分别为4.9%和18.6%。年轻POR患者亚组的CPR和胚胎移植后的LBR最高，随着母亲年龄的增加而降低。在三次尝试内，患者的CPR和LBR相似。
结论
总之，我们的研究支持定义IVF结局不良女性的博洛尼亚标准。但年龄小于42岁且首次进行3次IVF尝试的患者可获得可接受的CPR和LBR。
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