Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
J Gynecol Obstet Hum Reprod. 2021 Nov;50(9):102169. doi: 10.1016/j.jogoh.2021.102169. Epub 2021 May 24.
The present study was designed to compare the live birth rates (LBRs) according to Bologna criteria or Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number (POSEIDON) group classifications to determine the important predictive factors for LBR in patients with POR.
In this cross-sectional study, the database of Royan Institute (Tehran, Iran) from December 2015 to December 2017 was evaluated and the fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles outcomes for all the patients with at least one POR after standard controlled ovarian stimulation were collected. The patients divided into five subgroups according to Bologna criteria and four groups on the basis of POSEIDON group classification.
812 patients with POR diagnosis were assessed which 517 (63.6%) of them were underwent embryo transfer (ET) during the last treatment cycle. According to Bologna criteria, 41 patients were not included in any subgroup and the patients in Bologna group II had highest LBR (19.8%). In terms of POSEIDON classification, all of the patients were classified into subgroups and the women in POSEIDON group III had the highest LBR (27%). According to multivariable regression analysis, the significant independent predictive factors for LBR were the number and morphology (good and excellent) of the embryos transferred, and POSEIDON group III classification.
The results indicated that the POSEIDON group classification could be more comprehensive and practical than Bologna criteria for categorizing POR patients and predicting their outcome. Moreover, the number and morphology of transferred embryos were the most important prognostic factors for live births in these patients.
本研究旨在比较根据博洛尼亚标准或患者导向的涵盖个体化卵母细胞数的策略（POSEIDON）分组对活产率（LBR）的影响，以确定多囊卵巢综合征（POR）患者 LBR 的重要预测因素。
在这项横断面研究中，评估了伊朗 Royan 研究所（德黑兰）的数据库，该数据库收录了 2015 年 12 月至 2017 年 12 月期间接受标准控制性卵巢刺激后至少有一次 POR 的所有患者的受精/卵胞浆内单精子注射（IVF/ICSI）周期结果。患者根据博洛尼亚标准分为五个亚组，根据 POSEIDON 分组分类分为四个组。
评估了 812 例 POR 诊断患者，其中 517 例（63.6%）在最后一次治疗周期进行了胚胎移植（ET）。根据博洛尼亚标准，有 41 例患者未归入任何亚组，博洛尼亚组 II 患者的 LBR 最高（19.8%）。根据 POSEIDON 分类，所有患者均归入亚组，POSEIDON 组 III 患者的 LBR 最高（27%）。多变量回归分析显示，LBR 的独立预测因素是移植胚胎的数量和形态（良好和优秀）以及 POSEIDON 组 III 分类。
结果表明，POSEIDON 分组分类比博洛尼亚标准更全面、更实用，可以对 POR 患者进行分类，并预测其结局。此外，移植胚胎的数量和形态是这些患者活产的最重要的预后因素。
