Gooi Zhen, Chan Jason Y K, Fakhry Carole
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, U.S.A.
Department of Otorhinolaryngology-Head and Neck Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR.
Laryngoscope. 2016 Apr;126(4):894-900. doi: 10.1002/lary.25767. Epub 2016 Feb 4.
To summarize the epidemiology of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OSCC).
Articles in the English language referenced in MEDLINE/PubMed from the year 2000 onward.
Relevant articles pertaining to the epidemiology of HPV-related OSCC were selected for review, with a particular preference for articles from 2008 onward.
The incidence of HPV-related OSCC continues to increase in North America and Western Europe, with up to 70% of new oropharyngeal cancer cases being attributed to HPV, whereas data from the developing world remain lacking. There is evidence to support distinct risk factors for HPV-related OSCC as compared with HPV-unrelated OSCC. The long-term natural history of HPV infections remains unknown. HPV-related OSCC are associated with an improved prognosis both at the time of primary diagnosis and disease progression. There is preliminary evidence to show that HPV vaccination initiatives are effective in preventing HPV cervical infections, although data related to oral HPV infections are lacking.
The epidemiology of HPV-related OSCC is evolving. Further efforts are needed to characterize the natural history of oral HPV infection and its relationship with the eventual development of HPV-associated OSCC to develop effective tools for secondary prevention.
NA.
总结人乳头瘤病毒（HPV）相关的口咽鳞状细胞癌（OSCC）的流行病学情况。
2000年起MEDLINE/PubMed中引用的英文文章。
选取与HPV相关OSCC流行病学相关的文章进行综述，特别优先选取2008年起的文章。
北美和西欧HPV相关OSCC的发病率持续上升，高达70%的新发口咽癌病例归因于HPV，而发展中世界的数据仍然缺乏。有证据支持与非HPV相关OSCC相比，HPV相关OSCC存在不同的危险因素。HPV感染的长期自然史仍然未知。HPV相关OSCC在初次诊断和疾病进展时均与预后改善相关。有初步证据表明HPV疫苗接种举措可有效预防HPV宫颈感染，尽管缺乏与口腔HPV感染相关的数据。
HPV相关OSCC的流行病学在不断演变。需要进一步努力来明确口腔HPV感染的自然史及其与HPV相关OSCC最终发展的关系，以开发有效的二级预防工具。
无。
