Bubnova I A, Kuznetsov A V, Zelyanina E V, Bubnova I A, Kuznetsov A V, Zelyanina E V
Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021.
Vestn Oftalmol. 2015 Sep-Oct;131(5):38-42. doi: 10.17116/oftalma2015131538-42.
to study the efficacy of corneal collagen cross-linking in patients with progressive keratoconus over longer (up to 2 years) follow-up periods.
A total of 52 patients (104 eyes) aged 23-34 years with stage I-III progressive keratoconus were enrolled. Besides routine examinations (automatic refractometry, uncorrected and best corrected visual acuity (UCVA and BCVA) evaluation, pneumatic tonometry), Pentacam keratotopography and pachymetry ("Oculus", Germany) were performed in all cases. Corneal biomechanical properties were assessed with an Ocular Response Analyzer ("Reichert", USA). In all patients cross-linking procedure was carried out in the eye with more advanced keratoconus, the fellow eye being used as the control.
Judging from the results of UCVA and BCVA evaluation, keratotopography, and pachymetry obtained 2 years after the standard corneal cross-linking procedure, stabilization has been achieved in 97% of cases. In the remaining 3% of eyes corresponding parameters declined, although to a lesser extent than in the controls. Indices describing biomechanical properties of the cornea, such as corneal hysteresis, corneal resistance factor, as well as elastonometry results did not differ significantly throughout the whole observation period, which agrees with literature data.
Corneal collagen cross-linking has been proved capable of stopping keratoconus progression in most of the patients (97%). Further studies with even longer follow-up periods are needed.
通过更长（长达2年）的随访期，研究角膜胶原交联术对进展期圆锥角膜患者的疗效。
纳入52例年龄在23 - 34岁之间、患有I - III期进展期圆锥角膜的患者（104只眼）。除常规检查（自动验光、未矫正和最佳矫正视力（UCVA和BCVA）评估、气眼压计测量）外，所有病例均进行Pentacam角膜地形图和角膜厚度测量（德国“Oculus”）。使用眼反应分析仪（美国“Reichert”）评估角膜生物力学特性。所有患者均在圆锥角膜较严重的眼上进行交联手术，对侧眼作为对照。
从标准角膜交联手术后2年获得的UCVA和BCVA评估、角膜地形图和角膜厚度测量结果来看，97%的病例病情已稳定。其余3%的患眼相应参数有所下降，不过下降程度小于对照组。描述角膜生物力学特性的指标，如角膜滞后、角膜阻力因子以及弹性测量结果在整个观察期内无显著差异，这与文献数据相符。
角膜胶原交联术已被证明能够使大多数患者（97%）的圆锥角膜病情停止进展。需要进行更长随访期的进一步研究。
