Cui Xiang-Jun, Shi Chen-Xia
School of Mathematics, Physics and Biological Engineering, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Acta Biotheor. 2016 Jun;64(2):121-32. doi: 10.1007/s10441-016-9276-1. Epub 2016 Feb 5.
Histone post-translational modifications play important roles in transcriptional regulation. It is known that multiple histone modifications can act in a combinatorial manner. In this study, we investigated the effects of multiple histone modifications on expression levels of five gene categories (four kinds of pattern genes and non-pattern genes) in coding regions. The combinatorial patterns of modifications for the five gene categories were also studied in the regions. Our results indicated that the differences in the expression levels between any two gene categories were significant. There were some corresponding differences in multiple histone modification levels among the five gene categories. Multiple histone modifications jointly impacted expression levels of every gene category. Four mutual combinations of histone modifications were found and analyzed.
组蛋白翻译后修饰在转录调控中发挥着重要作用。已知多种组蛋白修饰可以以组合方式起作用。在本研究中，我们研究了多种组蛋白修饰对编码区中五类基因（四种模式基因和非模式基因）表达水平的影响。还在这些区域研究了五类基因修饰的组合模式。我们的结果表明，任意两类基因之间的表达水平差异显著。五类基因之间在多种组蛋白修饰水平上存在一些相应差异。多种组蛋白修饰共同影响每类基因的表达水平。发现并分析了四种组蛋白修饰的相互组合。
