Mahmood T A
Department of Obstetrics & Gynaecology, Raigmore Hospital, Inverness, Scotland.
Eur J Obstet Gynecol Reprod Biol. 1989 Nov;33(2):169-75. doi: 10.1016/0028-2243(89)90210-4.
Eighty primigravid patients with singleton pregnancies, cephalic presentation and unfavourable cervices (score less than 5) between 37 and 43 weeks gestation were studied prospectively to compare the ripening effect of vaginal PGE2 (3 mg) tablet with that of PGE2 gel (2 mg). Following the use of gel, the final mean cervical score was considerably improved and half of the patients went into spontaneous labour. The requirement for oxytocin augmentation was also reduced. The priming-to-induction and induction-to-delivery intervals were also considerably shortened in gel-treated patients. The proportion of patients delivered by Caesarean section in the gel group was lower than that in the tablet group (30 vs. 15%).
对80例单胎妊娠、头先露且宫颈条件不佳（评分低于5分）、孕周在37至43周之间的初产妇进行了前瞻性研究，以比较阴道用PGE2（3毫克）片剂与PGE2凝胶（2毫克）的促宫颈成熟效果。使用凝胶后，最终平均宫颈评分有显著改善，半数患者自发临产。催产素加强催产的需求也减少了。凝胶治疗组患者的促宫颈成熟至引产间隔以及引产至分娩间隔也显著缩短。凝胶组剖宫产分娩的患者比例低于片剂组（30%对15%）。
