正常血糖高胰岛素血症会增加人体骨骼肌中1,6-二磷酸葡萄糖的含量。

Euglycemic hyperinsulinemia increases glucose 1,6-bisphosphate in human skeletal muscle.

Katz A, Nyomba B L, Bogardus C

Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, Phoenix, AZ 85016.

Int J Biochem. 1989;21(10):1079-82. doi: 10.1016/0020-711x(89)90046-3.

Abstract

The effects of physiologic concentrations of insulin on the contents of glucose 1,6-bisphosphate (glucose 1,6-P2) and regulators of glucose 1,6-P2 synthase in intact human skeletal muscle have been investigated. 2. Insulin increased glucose 1,6-P2 from a basal value of 70 +/- 6 to 135 +/- 12 mumol/kg dry wt (P less than 0.001). 3. Activation of synthase could not be associated with changes in its inhibitors (fructose 1,6-P2, Pi, citrate) or its substrate glucose 6-P.

摘要

研究了生理浓度胰岛素对完整人体骨骼肌中1,6 - 二磷酸葡萄糖（葡萄糖1,6 - P2）含量及葡萄糖1,6 - P2合酶调节因子的影响。2. 胰岛素使葡萄糖1,6 - P2从基础值70±6增加至135±12μmol/kg干重（P<0.001）。3. 合酶的激活与它的抑制剂（1,6 - 二磷酸果糖、无机磷酸、柠檬酸）或其底物6 - 磷酸葡萄糖的变化无关。